Comprehensive functional genomic resource and integrative model for the human brain
INTRODUCTION Strong genetic associations have been found for a number of psychiatric
disorders. However, understanding the underlying molecular mechanisms remains …
disorders. However, understanding the underlying molecular mechanisms remains …
ADHD: Current concepts and treatments in children and adolescents
R Drechsler, S Brem, D Brandeis, E Grünblatt… - …, 2020 - thieme-connect.com
Attention deficit hyperactivity disorder (ADHD) is among the most frequent disorders within
child and adolescent psychiatry, with a prevalence of over 5%. Nosological systems, such as …
child and adolescent psychiatry, with a prevalence of over 5%. Nosological systems, such as …
Shared mechanisms across the major psychiatric and neurodegenerative diseases
Several common psychiatric and neurodegenerative diseases share epidemiologic risk;
however, whether they share pathophysiology is unclear and is the focus of our …
however, whether they share pathophysiology is unclear and is the focus of our …
Validity and utility of hierarchical taxonomy of psychopathology (HiTOP): I. Psychosis superspectrum
The Hierarchical Taxonomy of Psychopathology (HiTOP) is a scientific effort to address
shortcomings of traditional mental disorder diagnoses, which suffer from arbitrary …
shortcomings of traditional mental disorder diagnoses, which suffer from arbitrary …
[HTML][HTML] Live fast, die young? A review on the developmental trajectories of ADHD across the lifespan
Attention-deficit/hyperactivity disorder (ADHD) is highly heritable and the most common
neurodevelopmental disorder in childhood. In recent decades, it has been appreciated that …
neurodevelopmental disorder in childhood. In recent decades, it has been appreciated that …
Conduct disorder
Conduct disorder (CD) is a common and highly impairing psychiatric disorder that usually
emerges in childhood or adolescence and is characterized by severe antisocial and …
emerges in childhood or adolescence and is characterized by severe antisocial and …
Autism spectrum disorder at the crossroad between genes and environment: contributions, convergences, and interactions in ASD developmental pathophysiology
The complex pathophysiology of autism spectrum disorder encompasses interactions
between genetic and environmental factors. On the one hand, hundreds of genes …
between genetic and environmental factors. On the one hand, hundreds of genes …
Discovery of the first genome-wide significant risk loci for attention deficit/hyperactivity disorder
Attention deficit/hyperactivity disorder (ADHD) is a highly heritable childhood behavioral
disorder affecting 5% of children and 2.5% of adults. Common genetic variants contribute …
disorder affecting 5% of children and 2.5% of adults. Common genetic variants contribute …
Brain age prediction using deep learning uncovers associated sequence variants
Abstract Machine learning algorithms can be trained to estimate age from brain structural
MRI. The difference between an individual's predicted and chronological age, predicted age …
MRI. The difference between an individual's predicted and chronological age, predicted age …
Mendelian randomization accounting for correlated and uncorrelated pleiotropic effects using genome-wide summary statistics
Mendelian randomization (MR) is a valuable tool for detecting causal effects by using
genetic variant associations. Opportunities to apply MR are growing rapidly with the …
genetic variant associations. Opportunities to apply MR are growing rapidly with the …