Exploring the genetic overlap between twelve psychiatric disorders

C Romero, J Werme, PR Jansen, J Gelernter… - Nature …, 2022 - nature.com
The widespread comorbidity among psychiatric disorders demonstrated in epidemiological
studies,,,–is mirrored by non-zero, positive genetic correlations from large-scale genetic …

[HTML][HTML] Associations of immunological proteins/traits with schizophrenia, major depression and bipolar disorder: a bi-directional two-sample mendelian randomization …

BI Perry, R Upthegrove, N Kappelmann… - Brain, behavior, and …, 2021 - Elsevier
Background Schizophrenia, bipolar disorder and depression are associated with
inflammation. However, it is unclear whether associations of immunological proteins/traits …

Schizophrenia and the neurodevelopmental continuum: evidence from genomics

MJ Owen, MC O'Donovan - World Psychiatry, 2017 - Wiley Online Library
The idea that disturbances occurring early in brain development contribute to the
pathogenesis of schizophrenia, often referred to as the neurodevelopmental hypothesis, has …

[PDF][PDF] Getting to the cores of autism

LM Iakoucheva, AR Muotri, J Sebat - Cell, 2019 - cell.com
The genetic architecture of autism spectrum disorder (ASD) is itself a diverse allelic
spectrum that consists of rare de novo or inherited variants in hundreds of genes and …

Reviewing the genetics of heterogeneity in depression: operationalizations, manifestations and etiologies

N Cai, KW Choi, EI Fried - Human molecular genetics, 2020 - academic.oup.com
With progress in genome-wide association studies of depression, from identifying zero hits
in~ 16 000 individuals in 2013 to 223 hits in more than a million individuals in 2020 …

Dissecting polygenic signals from genome-wide association studies on human behaviour

A Abdellaoui, KJH Verweij - Nature Human Behaviour, 2021 - nature.com
Genome-wide association studies on human behavioural traits are producing large amounts
of polygenic signals with significant predictive power and potentially useful biological clues …

Physical exercise improves quality of life, depressive symptoms, and cognition across chronic brain disorders: a transdiagnostic systematic review and meta-analysis …

M Dauwan, MJH Begemann, MIE Slot, EHM Lee… - Journal of …, 2021 - Springer
We performed a meta-analysis to synthesize evidence on the efficacy and safety of physical
exercise as an add-on therapeutic intervention for quality of life (QoL), depressive symptoms …

Co‐morbidity between mood and anxiety disorders: A systematic review and meta‐analysis

S Saha, CCW Lim, DL Cannon, L Burton… - Depression and …, 2021 - Wiley Online Library
There is consistent evidence that mood disorders often co‐occur with anxiety disorders,
however, the strength of the association of these two broad groups of disorders has been …

Genetic identification of cell types underlying brain complex traits yields insights into the etiology of Parkinson's disease

J Bryois, NG Skene, TF Hansen, LJA Kogelman… - Nature …, 2020 - nature.com
Genome-wide association studies have discovered hundreds of loci associated with
complex brain disorders, but it remains unclear in which cell types these loci are active. Here …

GWAS of suicide attempt in psychiatric disorders and association with major depression polygenic risk scores

N Mullins, TB Bigdeli, AD Børglum… - American journal of …, 2019 - Am Psychiatric Assoc
Objective: More than 90% of people who attempt suicide have a psychiatric diagnosis;
however, twin and family studies suggest that the genetic etiology of suicide attempt is …