Exploring the genetic overlap between twelve psychiatric disorders
The widespread comorbidity among psychiatric disorders demonstrated in epidemiological
studies,,,–is mirrored by non-zero, positive genetic correlations from large-scale genetic …
studies,,,–is mirrored by non-zero, positive genetic correlations from large-scale genetic …
[HTML][HTML] Associations of immunological proteins/traits with schizophrenia, major depression and bipolar disorder: a bi-directional two-sample mendelian randomization …
Background Schizophrenia, bipolar disorder and depression are associated with
inflammation. However, it is unclear whether associations of immunological proteins/traits …
inflammation. However, it is unclear whether associations of immunological proteins/traits …
Schizophrenia and the neurodevelopmental continuum: evidence from genomics
MJ Owen, MC O'Donovan - World Psychiatry, 2017 - Wiley Online Library
The idea that disturbances occurring early in brain development contribute to the
pathogenesis of schizophrenia, often referred to as the neurodevelopmental hypothesis, has …
pathogenesis of schizophrenia, often referred to as the neurodevelopmental hypothesis, has …
[PDF][PDF] Getting to the cores of autism
The genetic architecture of autism spectrum disorder (ASD) is itself a diverse allelic
spectrum that consists of rare de novo or inherited variants in hundreds of genes and …
spectrum that consists of rare de novo or inherited variants in hundreds of genes and …
Reviewing the genetics of heterogeneity in depression: operationalizations, manifestations and etiologies
With progress in genome-wide association studies of depression, from identifying zero hits
in~ 16 000 individuals in 2013 to 223 hits in more than a million individuals in 2020 …
in~ 16 000 individuals in 2013 to 223 hits in more than a million individuals in 2020 …
Dissecting polygenic signals from genome-wide association studies on human behaviour
A Abdellaoui, KJH Verweij - Nature Human Behaviour, 2021 - nature.com
Genome-wide association studies on human behavioural traits are producing large amounts
of polygenic signals with significant predictive power and potentially useful biological clues …
of polygenic signals with significant predictive power and potentially useful biological clues …
Physical exercise improves quality of life, depressive symptoms, and cognition across chronic brain disorders: a transdiagnostic systematic review and meta-analysis …
M Dauwan, MJH Begemann, MIE Slot, EHM Lee… - Journal of …, 2021 - Springer
We performed a meta-analysis to synthesize evidence on the efficacy and safety of physical
exercise as an add-on therapeutic intervention for quality of life (QoL), depressive symptoms …
exercise as an add-on therapeutic intervention for quality of life (QoL), depressive symptoms …
Co‐morbidity between mood and anxiety disorders: A systematic review and meta‐analysis
There is consistent evidence that mood disorders often co‐occur with anxiety disorders,
however, the strength of the association of these two broad groups of disorders has been …
however, the strength of the association of these two broad groups of disorders has been …
Genetic identification of cell types underlying brain complex traits yields insights into the etiology of Parkinson's disease
Genome-wide association studies have discovered hundreds of loci associated with
complex brain disorders, but it remains unclear in which cell types these loci are active. Here …
complex brain disorders, but it remains unclear in which cell types these loci are active. Here …
GWAS of suicide attempt in psychiatric disorders and association with major depression polygenic risk scores
Objective: More than 90% of people who attempt suicide have a psychiatric diagnosis;
however, twin and family studies suggest that the genetic etiology of suicide attempt is …
however, twin and family studies suggest that the genetic etiology of suicide attempt is …