The epilepsies are commonly accompanied by widespread abnormalities in cerebral white
matter. ENIGMA-Epilepsy is a large quantitative brain imaging consortium, aggregating data …

Abstract Machine learning methods have been employed to make predictions in psychiatry
from genotypes, with the potential to bring improved prediction of outcomes in psychiatric …

Individual differences in cognitive performance increase with advancing age, reflecting
marked cognitive changes in some individuals along with little or no change in others …

The mechanisms by which common risk variants of small effect interact to contribute to
complex genetic disorders are unclear. Here, we apply a genetic approach, using isogenic …

Human genetics strongly support the involvement of synaptopathy in psychiatric disorders.
However, trans-scale causality linking synapse pathology to behavioral changes is lacking …

It has recently been proposed that a single dimension, called the p factor, can capture a
person's liability to mental disorder. Relevant to the p hypothesis, recent genetic research …

Schizophrenia is a highly polygenic disorder with important contributions from both common
and rare risk alleles. We analyzed exome sequencing data for de novo variants (DNVs) in a …

Genome-wide analyses of common and rare genetic variations have documented the
heritability of major psychiatric disorders, established their highly polygenic genetic …

Background: Abdominal aortic aneurysm (AAA) is an important cause of cardiovascular
mortality; however, its genetic determinants remain incompletely defined. In total, 10 …

BackgroundObsessive-compulsive disorder (OCD) is a psychiatric disorder with multiple
symptom dimensions (eg contamination, symmetry). OCD clusters in families and decades …