Voltage gated calcium channels (Ca2+ channels) are key mediators of depolarization
induced calcium influx into excitable cells, and thereby play pivotal roles in a wide array of …

The regulation of presynaptic, voltage-gated calcium channels by activation of heptahelical
G protein-coupled receptors exerts a crucial influence on presynaptic calcium entry and …

G protein-coupled receptors (GPCRs) transmit information to the cell interior by transducing
external signals to heterotrimeric G protein subunits, Gα and Gβγ subunits, localized on the …

Unique among the phospholipase C isozymes, the recently identified phospholipase C-ϵ
(PLC-ϵ) contains an amino-terminal CDC25 domain capable of catalyzing nucleotide …

We investigated the expression of Gγ13, a recently discovered G protein subunit, and a
selection of Gβ subunits in retinal bipolar cells, by using a transgenic mouse strain in which …

Voltage-gated Ca2+ channels translate the electrical inputs of excitable cells into
biochemical outputs by controlling influx of the ubiquitous second messenger Ca2+. As such …

Increasing evidence links the activation of Rho family GTPases to the stimulation of lipid
hydrolysis catalyzed by phospholipase C (PLC)-β isozymes. To better define this …

Background Specific interactions between G protein-coupled receptors (GPCRs) and G
proteins play a key role in mediating signaling events. While there is little doubt regarding …

The activation of G-protein-coupled olfactory receptors on the olfactory sensory neurons
(OSNs) triggers a signaling cascade, which is mediated by a heterotrimeric G-protein …

Agonist binding to G-protein–coupled receptors (GPCRs) triggers signal transduction
cascades involving heterotrimeric G proteins as key players. A major obstacle for drug …