The skin serves as the body's outermost barrier and is the largest organ, providing protection
not only to the body but also to various internal organs. Owing to continuous exposure to …

Chronic wounds represent a major therapeutic challenge. Lymphatic vessel function is
impaired in chronic ulcers but the role of lymphangiogenesis in wound healing has …

Hepatocellular carcinoma (HCC) progression is closely related to pathological fibrosis,
which involves heterotypic intercellular interactions (HIIs) between liver cancer cells and …

Autologous nerve grafting serves is considered the gold standard treatment for peripheral
nerve defects; however, limited availability and donor area destruction restrict its widespread …

The extracellular matrix (ECM) imparts critical mechanical and biochemical information to
cells in the lungs. Proteoglycans are essential constituents of the ECM and play a crucial …

Many key functions performed by the liver depend on the interaction between parenchymal
cells and the microenvironment comprised of neighboring cells and extracellular matrix. The …

Hydrogels with encapsulated cells have widespread biomedical applications, both as tissue-
mimetic 3D cultures in vitro and as tissue-engineered therapies in vivo. Within these …

Objective High stromal ratio of gastric cancer is associated with a poor prognosis.
Fibronectin 1 (FN1) is the main component of gastric cancer stroma. The focus of this …

Regenerative medicine affords an effective approach for restoring defect-associated
diseases, and biomaterials play a pivotal role as cell niches to support the cell behavior and …

The discovery that primary tumors condition distant organ sites of future metastasis for
seeding by disseminating tumor cells through a process described as the pre-metastatic …