Fibronectin isoforms in skeletal development and associated disorders

NEH Dinesh, PM Campeau… - American Journal of …, 2022 - journals.physiology.org
The extracellular matrix is an intricate and essential network of proteins and
nonproteinaceous components that provide a conducive microenvironment for cells to …

Nanoparticles traversing the extracellular matrix induce biophysical perturbation of fibronectin depicted by surface chemistry

X Guo, L Yang, C Deng, L Ren, S Li, X Zhang, J Zhao… - Nanoscale, 2024 - pubs.rsc.org
While the filtering and accumulation effects of the extracellular matrix (ECM) on
nanoparticles (NPs) have been experimentally observed, the detailed interactions between …

ECM substrates impact RNAi localization at adherens junctions of colon epithelial cells

AC Daulagala, A Kourtidis - Cells, 2022 - mdpi.com
The extracellular matrix (ECM) plays crucial roles in tissue homeostasis. Abnormalities in
ECM composition are associated with pathological conditions, such as fibrosis and cancer …

Formation of an invasion-permissive matrix requires TGFβ/SNAIL1-regulated alternative splicing of fibronectin

H Franco-Valls, E Tusquets-Uxó, L Sala, M Val… - Breast Cancer …, 2023 - Springer
Background As in most solid cancers, the emergence of cells with oncogenic mutations in
the mammary epithelium alters the tissue homeostasis. Some soluble factors, such as TGFβ …

Intelectin enhances the phagocytosis of macrophages via CDC42-WASF2-ARPC2 signaling axis in Megalobrama amblycephala

H Cui, Y Liu, Y Zheng, H Li, M Zhang, X Wang… - International Journal of …, 2023 - Elsevier
Intelectin has been identified in various vertebrates and plays an important role in the host
immune system. In our previous studies, recombinant Megalobrama amblycephala intelectin …

Employing extracellular matrix-based tissue engineering strategies for age-dependent tissue degenerations

Y Jo, SH Hwang, J Jang - International journal of molecular sciences, 2021 - mdpi.com
Tissues and organs are not composed of solely cellular components; instead, they converge
with an extracellular matrix (ECM). The composition and function of the ECM differ …

Delivery technologies for therapeutic targeting of fibronectin fibrosis in autoimmunity and applications

JD Bonadio, G Bashiri, P Halligan, M Kegel… - Advanced Drug Delivery …, 2024 - Elsevier
Fibronectin (FN) is a critical component of extracellular matrix (ECM) contributing to various
physiological processes, including tissue repair and immune response regulation. FN …

Unraveling the role of epithelial–mesenchymal transition in adenoid cystic carcinoma of the salivary glands: a comprehensive review

CC Hoch, F Stögbauer, B Wollenberg - Cancers, 2023 - mdpi.com
Simple Summary Salivary adenoid cystic carcinoma (SACC) is an aggressive tumor that
exhibits a neurotropic growth pattern by invading nerve fibers and demonstrates a high …

The role of fibronectin in mediating cell migration

JH Longstreth, K Wang - American Journal of Physiology …, 2024 - journals.physiology.org
Fibronectin (FN) is a major extracellular matrix (ECM) protein involved in a wide range of
physiological processes, including cell migration. These FN-mediated cell migration events …

Regenerative engineering approaches to scar-free skin regeneration

T Otsuka, HM Kan, CT Laurencin - Regenerative Engineering and …, 2022 - Springer
Skin is the largest organ of the human body. It is highly susceptible to injury. Typically, adult
skin wounds heal via scar formation rather than regeneration. Thus, skin presents an …