Microglia, characterized by responding to damage, regulating the secretion of soluble
inflammatory mediators, and engulfing specific segments in the central nervous system …

Cell regulatory networks are the determinants of cellular homeostasis. Any alteration to
these networks results in the disturbance of cellular homeostasis and induces cells towards …

Tumour‐associated macrophages (TAMs) abundantly infiltrate high‐grade gliomas and
orchestrate immune response, but their diversity in isocitrate dehydrogenase (IDH) …

Alzheimer's disease (AD) is a prevalent type of dementia in elderly populations with a
significant genetic component. The accumulating evidence suggests that AD involves a …

Abstract Background Late-onset Alzheimer's disease (LOAD) is the most common form of
dementia; it disproportionally affects women in terms of both incidence rates and severity of …

The family of myocyte enhancer factor 2 (MEF2) transcription factors comprises four highly
conserved members that play an important role in the nervous system. They appear in …

Lipid mediators are important regulators in inflammatory responses, and their biosynthetic
pathways are targeted by commonly used anti-inflammatory drugs. Switching from pro …

Background Enhancers are regulatory elements that target and modulate gene expression
and play a role in human health and disease. However, the roles of enhancer regulatory …

Traumatic brain injury (TBI) causes a prolonged inflammatory response in the central
nervous system (CNS) driven by microglia. Microglial reactivity is exacerbated by stress …

Alzheimer's disease (AD) is the most common neurodegenerative disease. More and more
evidence show that DNA methylation is closely related to the pathological mechanism of AD …