Five decades ago, seminal studies positioned the brainstem locus coeruleus (LC)
norepinephrine (NE) system as a key substrate for the regulation of wakefulness and sleep …

Disruptions to dopamine and noradrenergic neurotransmission are noted in several
neurodegenerative and psychiatric disorders. Neuromelanin-sensitive (NM)-MRI offers a …

Alzheimer's disease (AD) is a progressive and deleterious neurodegenerative disease,
strongly affecting the cognitive functions and memory of seniors worldwide. Around 58% of …

The locus coeruleus (LC) is a small brainstem structure located in the lower pons and is the
main source of noradrenaline (NA) in the brain. Via its phasic and tonic firing, it modulates …

Background Degeneration of the locus coeruleus (LC) noradrenergic system contributes to
clinical symptoms in Alzheimer's disease (AD) and Parkinson's disease (PD). Diffusion …

Alzheimer's disease (AD) is caused by cortical degeneration leading to memory loss and
dementia. A possible criterion for the early identification of Alzheimer's dementia is to identify …

Here an overview is provided on therapeutic/neuroprotective effects of Lithium (Li+) in
neurodegenerative and psychiatric disorders focusing on the conspicuous action of Li+ …

Recent technological improvements have positioned us at the threshold of innovative
discoveries that will assist in new perspectives and avenues of research. Increased attention …

Locus Coeruleus (LC) is the main noradrenergic nucleus of the brain, which is involved in
many physiological functions including cognition; its impairment may be crucial in the …

Background There has been increasing interest in cortical microstructure as a
complementary and earlier measure of neurodegeneration than macrostructural atrophy, but …