Inflammatory bowel disease (IBD) is an immune-mediated disease of the intestinal tract, with
complex pathophysiology involving genetic, environmental, microbiome, immunological and …

Systemic lupus erythematosus (SLE) is an autoimmune disease characterized by loss of
immune tolerance and sustained production of autoantibodies. Multiple and profound T cell …

Epigenetic pathways play a pivotal role in the development and function of the immune
system. Over the last decade, a growing body of studies has been published out seeking to …

Aging of the immune system in humans and animals is characterized by a decline in both
adaptive and innate immune responses. Paradoxically, aging is also associated with a state …

Autoimmune diseases are usually complex and multifactorial, characterized by aberrant
production of autoreactive immune cells and/or autoantibodies against healthy cells and …

Twin studies are powerful tools to discriminate whether a complex disease is due to genetic
or environmental factors. High concordance rates among monozygotic (MZ) twins support …

ABSTRACT Introduction: Guillain-Barré syndrome is a rare disease representing the most
frequent cause of acute flaccid symmetrical weakness of the limbs and areflexia usually …

IgA is the most abundant immunoglobulin in the human body, and performs a very
specialized role which involves mucosal immunity, development of tolerance and protection …

TET2, a member of ten-eleven translocation (TET) family as α-ketoglutarate-and Fe2+-
dependent dioxygenase catalyzing the iterative oxidation of 5-methylcytosine (5mC), has …

Objectives Non-selective histone deacetylase (HDAC) inhibitors (HDACi) have
demonstrated anti-inflammatory properties in both in vitro and in vivo models of rheumatoid …