Mesenchymal stem cells (MSCs) are non-hematopoietic progenitor cells with self-renewal
ability and multipotency of osteogenic, chondrogenic, and adipogenic differentiation. MSCs …

Converting genetic information into functional proteins is a complex, multi-step process, with
each step being tightly regulated to ensure the accuracy of translation, which is critical to …

In bacteria, the translation of genetic information can begin through at least three different
mechanisms: canonical or Shine-Dalgarno-led initiation, readthrough or 70S scanning …

Genetic engineering is an efficient approach to improve fungal bioproducts, but the specific
targets are limited. In this study, it was found that the key transcription repressor CxrC of …

Increasing numbers of antimalarial compounds are being identified that converge
mechanistically at inhibition of cytoplasmic translation, regardless of the molecular target or …

Protein phosphorylation is a universal mechanism regulating a wide range of cellular
responses across all domains of life. The antagonistic activities of kinases and …

Amino acids are essential for the activation of the mechanistic target of rapamycin (mTOR),
but the corresponding molecular mechanism is not yet fully understood. We previously found …

Cellular plasticity is crucial for adapting to ever-changing stimuli. As a result, cells
consistently reshape their translatome, and, consequently, their proteome. The control of …

Non-classical secretory proteins are widely found in bacteria and have been extensively
studied due to their important physiological roles. However, the relevant non-classical …

Endoplasmic Reticulum (ER) stress, caused by the accumulation of misfolded proteins in the
ER, elicits a homeostatic mechanism known as the Unfolded Protein Response (UPR). The …