Short-read, high-throughput sequencing (HTS) methods have yielded numerous important
insights into microbial ecology and function. Yet, in many instances short-read HTS …

Bisulfite sequencing is a powerful technique to detect 5-methylcytosine in DNA that has
immensely contributed to our understanding of epigenetic regulation in plants and animals …

As long-read sequencing technologies continue to advance, the possibility of obtaining
maps of DNA and RNA modifications at single-molecule resolution has become a reality …

The origin story and emergence of molecular biology is muddled. The early triumphs in
bacterial genetics and the complexity of animal and plant genomes complicate an intricate …

DNA-editing enzymes perform chemical reactions on DNA nucleobases. These reactions
can change the genetic identity of the modified base or modulate gene expression. Interest …

Forkhead box O (FOXO) transcription factors (TFs) are a subclass of the larger family of
forkhead TFs. Mammalians express four members FOXO1, FOXO3, FOXO4, and FOXO6 …

Epigenetic modifications play a vital role in the preservation of genome integrity and in the
regulation of gene expression. DNA methylation, one of the key mechanisms of epigenetic …

Conspectus As part of the classic central dogma of molecular biology, transfer RNAs
(tRNAs) are integral to protein translation as the adaptor molecules that link the genetic code …

MODOMICS is an established database of RNA modifications that provides comprehensive
information concerning chemical structures of modified ribonucleosides, their biosynthetic …

Abstract DNA N4-methylcytosine (4mC) modification represents a novel epigenetic
regulation. It involves in various cellular processes, including DNA replication, cell cycle and …