DNA methylation-based predictors of health: applications and statistical considerations
DNA methylation data have become a valuable source of information for biomarker
development, because, unlike static genetic risk estimates, DNA methylation varies …
development, because, unlike static genetic risk estimates, DNA methylation varies …
[HTML][HTML] Machine learning and clinical epigenetics: a review of challenges for diagnosis and classification
Background Machine learning is a sub-field of artificial intelligence, which utilises large data
sets to make predictions for future events. Although most algorithms used in machine …
sets to make predictions for future events. Although most algorithms used in machine …
Epigenetic patterns in blood associated with lipid traits predict incident coronary heart disease events and are enriched for results from genome-wide association …
Background—Genome-wide association studies have identified loci influencing circulating
lipid concentrations in humans; further information on novel contributing genes, pathways …
lipid concentrations in humans; further information on novel contributing genes, pathways …
[HTML][HTML] DNA methylation map in circulating leukocytes mirrors subcutaneous adipose tissue methylation pattern: a genome-wide analysis from non-obese and obese …
The characterization of the epigenetic changes within the obesity-related adipose tissue will
provide new insights to understand this metabolic disorder, but adipose tissue is not easy to …
provide new insights to understand this metabolic disorder, but adipose tissue is not easy to …
Perspectives and challenges of epigenetic determinants of childhood obesity: a systematic review
R Alfano, O Robinson, E Handakas, TS Nawrot… - Obesity …, 2022 - Wiley Online Library
The tremendous increase in childhood obesity prevalence over the last few decades cannot
merely be explained by genetics and evolutionary changes in the genome, implying that …
merely be explained by genetics and evolutionary changes in the genome, implying that …
[HTML][HTML] A multi-ethnic epigenome-wide association study of leukocyte DNA methylation and blood lipids
Here we examine the association between DNA methylation in circulating leukocytes and
blood lipids in a multi-ethnic sample of 16,265 subjects. We identify 148, 35, and 4 novel …
blood lipids in a multi-ethnic sample of 16,265 subjects. We identify 148, 35, and 4 novel …
[HTML][HTML] The association of DNA methylation with body mass index: distinguishing between predictors and biomarkers
Background DNA methylation is associated with body mass index (BMI), but it is not clear if
methylation scores are biomarkers for extant BMI or predictive of future BMI. Here, we …
methylation scores are biomarkers for extant BMI or predictive of future BMI. Here, we …
[HTML][HTML] DNA methylation signature in blood mirrors successful weight-loss during lifestyle interventions: the CENTRAL trial
Background One of the major challenges in obesity treatment is to explain the high
variability in the individual's response to specific dietary and physical activity interventions …
variability in the individual's response to specific dietary and physical activity interventions …
[HTML][HTML] An integrative cross-omics analysis of DNA methylation sites of glucose and insulin homeostasis
Despite existing reports on differential DNA methylation in type 2 diabetes (T2D) and
obesity, our understanding of its functional relevance remains limited. Here we show the …
obesity, our understanding of its functional relevance remains limited. Here we show the …
Epigenetic alterations of the BDNF gene in combat‐related post‐traumatic stress disorder
Objective Brain‐derived neurotrophic factor (BDNF) plays a crucial role in modulating
resilience and vulnerability to stress. The aim of this study was to investigate whether …
resilience and vulnerability to stress. The aim of this study was to investigate whether …