The development of small-molecule calcitonin gene-related peptide (CGRP) receptor
antagonists (gepants) and of monoclonal antibodies targeting the CGRP system has been a …

Major advances in our understanding of the functional heterogeneity of enteric neurons are
driven by the application of newly developed, innovative methods. In contrast to this …

The porcine intestinal tract possesses functional and pathological similarities to the human
digestive tract and the organization of the porcine enteric nervous system, like that of the …

1 Introduction The plexuses of Auerbach and Meissner are peculiar to the gut; they extend
from the beginning of the unstriated portion of the oesophagus to the end of the rectum. They …

Pseudouni-or multiaxonal Dogiel type II neurons are the intrinsic primary afferent (sensory)
neurons (IPANs) in the guinea pig small intestine. Our aim was to decipher the chemical …

Somatostatin (SOM) is an active substance which most commonly occurs in endocrine cells,
as well as in the central and peripheral nervous system. One of the parts of the nervous …

Lipofuscin, an autofluorescent age pigment, occurs in enteric neurons. Due to its broad
excitation and emission spectra, it overlaps with commonly used fluorophores in …

To investigate extrinsic origins of calcitonin gene-related peptide immunoreactive (CGRP-
IR) nerve fibres in the sheep ileum, the retrograde fluorescent tracer Fast Blue (FB) was …

Most myenteric neurons contain one of the two generating enzymes for major excitatory and
inhibitory neurotransmitters: choline acetyltransferase (ChAT) or neuronal nitric oxide …

Aims The diagnosis of Hirschsprung's disease is currently based on the identification of
aganglionosis and the presence of an increase in acetylcholinesterase‐positive …