Hepatocellular carcinoma: signaling pathways, targeted therapy, and immunotherapy

X Luo, X He, X Zhang, X Zhao, Y Zhang, Y Shi… - MedComm, 2024 - Wiley Online Library
Hepatocellular carcinoma (HCC) is the most common primary liver cancer with a high
mortality rate. It is regarded as a significant public health issue because of its complicated …

[HTML][HTML] Cancer cell genetics shaping of the tumor microenvironment reveals myeloid cell-centric exploitable vulnerabilities in hepatocellular carcinoma

CFA Ramirez, D Taranto, M Ando-Kuri… - Nature …, 2024 - nature.com
Myeloid cells are abundant and plastic immune cell subsets in the liver, to which pro-
tumorigenic, inflammatory and immunosuppressive roles have been assigned in the course …

Battle of the biopsies: Role of tissue and liquid biopsy in hepatocellular carcinoma

BM Lehrich, J Zhang, SP Monga, R Dhanasekaran - Journal of hepatology, 2023 - Elsevier
Hepatocellular carcinoma (HCC) diagnosis and management have undergone significant
improvements in recent years. With the introduction of immunotherapy-based combination …

[HTML][HTML] Exploring the mechanism of aloe-emodin in the treatment of liver cancer through network pharmacology and cell experiments

M Zhu, Q He, Y Wang, L Duan, K Rong, Y Wu… - Frontiers in …, 2023 - frontiersin.org
Objective: Aloe-emodin (AE) is an anthraquinone compound extracted from the rhizome of
the natural plant rhubarb. Initially, it was shown that AE exerts an anti-inflammatory effect …

[HTML][HTML] The double-edged sword role of hydrogen sulfide in hepatocellular carcinoma

H Zhao, Y Zhang, X Fu, C Chen, S Khattak… - Frontiers in …, 2023 - frontiersin.org
With an increasing worldwide prevalence, hepatocellular carcinoma (HCC) is the most
common primary malignant tumor of the liver in the world. It is also the primary reason for …

[HTML][HTML] The anti-hepatocellular carcinoma effect of Aidi injection was related to the synergistic action of cantharidin, formononetin, and isofraxidin through BIRC5 …

S Lu, J Huang, J Zhang, C Wu, Z Huang, X Tao… - Journal of …, 2024 - Elsevier
Ethnopharmacological relevance Aidi injection (ADI) is a popular anti-tumor Chinese patent
medicine, widely used in clinics for the treatment of hepatocellular carcinoma (HCC) with …

[HTML][HTML] TANGO1 interacts with NRTN to promote hepatocellular carcinoma progression by regulating the PI3K/AKT/mTOR signaling pathway

J Man, W Zhou, S Zuo, X Zhao, Q Wang, H Ma… - Biochemical …, 2023 - Elsevier
Transport and Golgi organization 1 (TANGO1) also known as MIA3, belongs to the
melanoma inhibitory activity gene (MIA) family together with MIA, MIA2 and OTOR; these …

[HTML][HTML] Natural products in digestive tract tumors metabolism: Functional and application prospects

P Xing, Y Zhong, X Cui, Z Liu, X Wu - Pharmacological Research, 2023 - Elsevier
Digestive tract diseases are presently the hotspot of clinical diagnosis and treatment, and
the incidence of digestive tract tumor is increasing annually. Surgery remains the main …

Targeted degradation of NDUFS1 by agrimol B promotes mitochondrial ROS accumulation and cytotoxic autophagy arrest in hepatocellular carcinoma

L Dong, L Luo, Z Wang, S Lian, M Wang, X Wu… - Free Radical Biology …, 2024 - Elsevier
Hepatocellular carcinoma (HCC) is a global public health problem with increased morbidity
and mortality. Agrimol B, a natural polyphenol, has been proved to be a potential anticancer …

Targeted liposomes encapsulated iridium (III) compound greatly enhance anticancer efficacy and induce cell death via ferroptosis on HepG2 cells

J Chen, W Li, G Li, X Liu, C Huang, H Nie… - European Journal of …, 2024 - Elsevier
In this study, ligands 2-phenyl-1H-imidazo [4, 5-f][1, 10] phenanthroline (PIP), 2-(2-
nitrophenyl)-1H-imidazo [4, 5-f][1, 10] phenanthroline (NPIP), 2-(2-nitronaphthalen-1-yl)-1H …