Enzymatic noncovalent synthesis
Enzymatic reactions and noncovalent (ie, supramolecular) interactions are two fundamental
nongenetic attributes of life. Enzymatic noncovalent synthesis (ENS) refers to a process …
nongenetic attributes of life. Enzymatic noncovalent synthesis (ENS) refers to a process …
Assembly and trafficking of box C/D and H/ACA snoRNPs
S Massenet, E Bertrand, C Verheggen - RNA biology, 2017 - Taylor & Francis
Box C/D and box H/ACA snoRNAs are abundant non-coding RNAs that localize in the
nucleolus and mostly function as guides for nucleotide modifications. While a large pool of …
nucleolus and mostly function as guides for nucleotide modifications. While a large pool of …
Small Cajal body-associated RNA 2 (scaRNA2) regulates DNA repair pathway choice by inhibiting DNA-PK
S Bergstrand, EM O'Brien, C Coucoravas… - Nature …, 2022 - nature.com
Evidence that long non-coding RNAs (lncRNAs) participate in DNA repair is accumulating,
however, whether they can control DNA repair pathway choice is unknown. Here we show …
however, whether they can control DNA repair pathway choice is unknown. Here we show …
[HTML][HTML] VRK1 variants at the cross road of Cajal body neuropathogenic mechanisms in distal neuropathies and motor neuron diseases
PA Lazo, P Morejón-García - Neurobiology of Disease, 2023 - Elsevier
Distal hereditary neuropathies and neuro motor diseases are complex neurological
phenotypes associated with pathogenic variants in a large number of genes, but in some the …
phenotypes associated with pathogenic variants in a large number of genes, but in some the …
Coilin: The first 25 years
M Machyna, KM Neugebauer, D Staněk - RNA biology, 2015 - Taylor & Francis
Initially identified as a marker of coiled bodies (now Cajal bodies or CBs), the protein coilin
was discovered a quarter of century ago. Coilin is now known to scaffold the CB, but its …
was discovered a quarter of century ago. Coilin is now known to scaffold the CB, but its …
Biology and clinical relevance of noncoding sno/scaRNAs
T Cao, S Rajasingh, S Samanta, B Dawn… - Trends in cardiovascular …, 2018 - Elsevier
Small nucleolar RNAs (snoRNAs) are a group of noncoding RNAs that perform various
biological functions, including biochemical modifications of other RNAs, precursors of …
biological functions, including biochemical modifications of other RNAs, precursors of …
TDP-43 regulates site-specific 2′-O-methylation of U1 and U2 snRNAs via controlling the Cajal body localization of a subset of C/D scaRNAs
K Izumikawa, Y Nobe, H Ishikawa… - Nucleic acids …, 2019 - academic.oup.com
TDP-43 regulates cellular levels of Cajal bodies (CBs) that provide platforms for the
assembly and RNA modifications of small nuclear ribonucleoproteins (snRNPs) involved in …
assembly and RNA modifications of small nuclear ribonucleoproteins (snRNPs) involved in …
Towards an understanding of regulating Cajal body activity by protein modification
MD Hebert, AR Poole - RNA biology, 2017 - Taylor & Francis
The biogenesis of small nuclear ribonucleoproteins (snRNPs), small Cajal body-specific
RNPs (scaRNPs), small nucleolar RNPs (snoRNPs) and the telomerase RNP involves Cajal …
RNPs (scaRNPs), small nucleolar RNPs (snoRNPs) and the telomerase RNP involves Cajal …
VRK1 regulates Cajal body dynamics and protects coilin from proteasomal degradation in cell cycle
L Cantarero, M Sanz-García, H Vinograd-Byk… - Scientific reports, 2015 - nature.com
Cajal bodies (CBs) are nuclear organelles associated with ribonucleoprotein functions and
RNA maturation. CBs are assembled on coilin, its main scaffold protein, in a cell cycle …
RNA maturation. CBs are assembled on coilin, its main scaffold protein, in a cell cycle …
Nopp140-mediated concentration of telomerase in Cajal bodies regulates telomere length
Cajal bodies (CBs) are nuclear organelles concentrating two kinds of RNA–protein
complexes (RNPs), spliceosomal small nuclear (sn), and small CB-specific (sca) RNPs …
complexes (RNPs), spliceosomal small nuclear (sn), and small CB-specific (sca) RNPs …