Although much progress has been achieved in the development of cancer therapies in
recent decades, problems continue to arise particularly with respect to chemotherapy due to …

Engineered nanomaterials that produce reactive oxygen species on exposure to X‐and
gamma‐rays used in radiation therapy offer promise of novel cancer treatment strategies …

Purpose Valproic acid (VPA) is an antiepileptic agent with histone deacetylase inhibitor
(HDACi) activity shown to sensitize glioblastoma (GBM) cells to radiation in preclinical …

Upregulation of NADPH oxidases (NOXs) in cancer cells leads to chronic increase in
intracellular reactive oxygen species (ROS) and adaptation to a high ROS level for cell …

Although radiation therapy (RT) is an integral component of treatment of patients with many
types of cancer, inherent and/or acquired resistance to the cytotoxic effects of RT is …

Nanoparticle delivery to solid tumors is a prime challenge in nanomedicine. Here, we
approach this challenge through the lens of biogeochemistry, the field that studies the flow of …

Background Histone deacetylase (HDAC) inhibitors have shown radiosensitising activity in
preclinical tumour models. This phase 1 study assessed the use of vorinostat combined with …

We have uncovered a role for Jumonji inhibitors in overcoming radioresistance through
KDM5B inhibition. Pharmacological blockade of Jumonji demethylases with JIB-04 leads to …

Radiosensitizers are compounds or nanostructures, which can improve the efficiency of
ionizing radiation to kill cells. Radiosensitization increases the susceptibility of cancer cells …

Circular RNAs (circRNAs) play critical roles in regulating the radiosensitivity of various
cancers, including esophageal squamous cell carcinoma (ESCC). This research aimed to …