Therapeutic targeting of factor D and MASP3 in complement‐mediated diseases: Lessons learned from mouse studies
E Mohammadyari, T Miwa, M Golla… - European Journal of …, 2024 - Wiley Online Library
The alternative pathway (AP) plays a major role in many complement‐mediated human
diseases. Factor D (FD), a rate‐limiting enzyme in AP complement activation, is an attractive …
diseases. Factor D (FD), a rate‐limiting enzyme in AP complement activation, is an attractive …
Targeted genotyping of COVID-19 patients reveals a signature of complement C3 and factor B coding SNPs associated with severe infection
SA Tsiftsoglou, E Gavriilaki, T Touloumenidou… - Immunobiology, 2023 - Elsevier
We have attempted to explore further the involvement of complement components in the
host COVID-19 (Coronavirus disease-19) immune responses by targeted genotyping of …
host COVID-19 (Coronavirus disease-19) immune responses by targeted genotyping of …
[PDF][PDF] The complement system is linked to insulin resistance in patients with systemic lupus erythematosus
M García-González, F Gómez-Bernal… - Clin Exp …, 2023 - clinexprheumatol.org
Objective Systemic lupus erythematosus (SLE) patients more commonly have insulin
resistance (IR) than control subjects. Recent studies have revealed that the complement (C) …
resistance (IR) than control subjects. Recent studies have revealed that the complement (C) …
[HTML][HTML] Heme Interactions as Regulators of the Alternative Pathway Complement Responses and Implications for Heme-Associated Pathologies
SA Tsiftsoglou - Current Issues in Molecular Biology, 2023 - mdpi.com
Heme (Fe2+-protoporphyrin IX) is a pigment of life, and as a prosthetic group in several
hemoproteins, it contributes to diverse critical cellular processes. While its intracellular levels …
hemoproteins, it contributes to diverse critical cellular processes. While its intracellular levels …
A selective alternative pathway complement inhibitor for treatment of paroxysmal nocturnal hemoglobinuria
H Sülzen, H Tulmin, M Hájek, J Čermák, A Kadlecová… - bioRxiv, 2024 - biorxiv.org
The complement system, a critical component of the human innate immune system,
enhances the ability to clear microbes and damaged cells. Dysregulation of this system …
enhances the ability to clear microbes and damaged cells. Dysregulation of this system …