The presence of epoxyeicosatrienoic acids (EETs) in tissues and their metabolism by
soluble epoxide hydrolase (sEH) to 1, 2-diols were first reported 30 years ago. However …

Eicosanoids are biologically active lipid signaling molecules derived from polyunsaturated
fatty acids. Many of the actions of eicosanoid metabolites formed by cyclooxygenase and …

Mammalian soluble epoxide hydrolase (sEH) converts epoxides to their corresponding diols
through the addition of a water molecule. sEH readily hydrolyzes lipid signaling molecules …

A great deal of interest in psychiatric research is currently centered upon the pathogenic role
of inflammatory processes. Positron emission tomography (PET) using radiolabeled ligands …

Beneficial physiological effects of long-chain n-3 polyunsaturated fatty acids are widely
accepted but the mechanism (s) by which these fatty acids act remains unclear. Herein, we …

Epoxide hydrolases catalyse the hydrolysis of electrophilic—and therefore potentially
genotoxic—epoxides to the corresponding less reactive vicinal diols, which explains the …

Pinocembrin is a natural flavonoid compound extracted from honey, propolis, ginger roots,
wild marjoram, and other plants. In preclinical studies, it has shown anti-inflammatory and …

There is considerable interest in the therapeutic and adverse outcomes of drug interactions
at the blood-brain barrier (BBB) and the blood-cerebrospinal fluid barrier (BCSFB). These …

Even after decades of research, the mechanism of neurodegeneration remains
understudied, hindering the discovery of effective treatments for neurodegenerative …

Around the world, cancer remains one of the most important causes of morbidity and
mortality. Worldwide, approximately 238,000 new cases of brain and other central nervous …