RNA helicases are highly conserved proteins that use nucleoside triphosphates to bind or
remodel RNA, RNA–protein complexes or both. RNA helicases are classified into the DEAD …

The exon junction complex (EJC) is deposited onto mRNAs following splicing and adopts a
unique structure, which can both stably bind to mRNAs and function as an anchor for diverse …

RNA helicases are critical regulators at the nexus of multiple pathways of RNA metabolism,
and in the complex cellular environment, tight spatial and temporal regulation of their activity …

Eukaryotic initiation factor 4A-III (eIF4A3), a core helicase component of the exon junction
complex, is essential for splicing, mRNA trafficking, and nonsense-mediated decay …

RNA helicases of the DEAH/RHA family form a large and conserved class of enzymes that
remodel RNA protein complexes (RNPs) by translocating along the RNA. Driven by ATP …

Ribosome synthesis requires a multitude of cofactors, among them DExD/H-box RNA
helicases. Bacterial RNA helicases involved in ribosome assembly are not essential, while …

DEAD-box helicases catalyze the ATP-dependent unwinding of RNA duplexes. They share
a helicase core formed by two RecA-like domains that carries a set of conserved motifs …

The exon junction complex (EJC) is an RNA binding complex comprised of the core
components Magoh, Rbm8a, and Eif4a3. Human mutations in EJC components cause …

Richieri-Costa-Pereira syndrome is an autosomal-recessive acrofacial dysostosis
characterized by mandibular median cleft associated with other craniofacial anomalies and …

Dynamic regulation of RNA folding and structure is critical for the biogenesis and function of
RNAs and ribonucleoprotein (RNP) complexes. Through their nucleotide triphosphate …