Bone pain in cancer patients: mechanisms and current treatment
R Zajączkowska, M Kocot-Kępska, W Leppert… - International journal of …, 2019 - mdpi.com
The skeletal system is the third most common site for cancer metastases, surpassed only by
the lungs and liver. Many tumors, especially those of the breast, prostate, lungs, and …
the lungs and liver. Many tumors, especially those of the breast, prostate, lungs, and …
Microenvironment-responsive nanocarriers for targeted bone disease therapy
M Li, B Yu, S Wang, F Zhou, J Cui, J Su - Nano Today, 2023 - Elsevier
Nanomedicines with controlled drug release have received increasing attention as an
advanced therapeutic strategy for bone diseases. To traverse biological barriers towards …
advanced therapeutic strategy for bone diseases. To traverse biological barriers towards …
Subchondral bone osteoclasts induce sensory innervation and osteoarthritis pain
Joint pain is the defining symptom of osteoarthritis (OA) but its origin and mechanisms
remain unclear. Here, we investigated an unprecedented role of osteoclast-initiated …
remain unclear. Here, we investigated an unprecedented role of osteoclast-initiated …
Stimuli-responsive nanocarriers for delivery of bone therapeutics–Barriers and progresses
The development of stimuli-responsive nanomedicines with tunable cargo release is
gathering an increased applicability in bone regeneration and precision biomedicine. Yet …
gathering an increased applicability in bone regeneration and precision biomedicine. Yet …
Mechanisms of cancer pain
R Haroun, JN Wood, S Sikandar - Frontiers in Pain Research, 2023 - frontiersin.org
Personalised and targeted interventions have revolutionised cancer treatment and
dramatically improved survival rates in recent decades. Nonetheless, effective pain …
dramatically improved survival rates in recent decades. Nonetheless, effective pain …
Acid-sensing ion channel 3: An analgesic target
Acid-sensing ion channel 3 (ASIC3) belongs to the epithelial sodium channel/degenerin
(ENaC/DEG) superfamily. There are 7 different ASIC subunits encoded by 5 different genes …
(ENaC/DEG) superfamily. There are 7 different ASIC subunits encoded by 5 different genes …
Bone metastasis pain, from the bench to the bedside
F Aielli, M Ponzetti, N Rucci - International Journal of Molecular Sciences, 2019 - mdpi.com
Bone is the most frequent site of metastasis of the most common cancers in men and
women. Bone metastasis incidence has been steadily increasing over the years, mainly …
women. Bone metastasis incidence has been steadily increasing over the years, mainly …
Innervation is higher above bone remodeling surfaces and in cortical pores in human bone: lessons from patients with primary hyperparathyroidism
M Sayilekshmy, RB Hansen, JM Delaissé, L Rolighed… - Scientific reports, 2019 - nature.com
Mounting evidence from animal studies suggests a role of the nervous system in bone
physiology. However, little is known about the nerve fiber localization to human bone …
physiology. However, little is known about the nerve fiber localization to human bone …
[HTML][HTML] Inhibition of TRPV1 by SHP-1 in nociceptive primary sensory neurons is critical in PD-L1 analgesia
BL Liu, QL Cao, X Zhao, HZ Liu, YQ Zhang - JCI insight, 2020 - ncbi.nlm.nih.gov
Recently programmed death-ligand 1 (PD-L1) receptor PD-1 was found in dorsal root
ganglion (DRG) neurons, and PD-L1 activates PD-1 to inhibit inflammatory and neuropathic …
ganglion (DRG) neurons, and PD-L1 activates PD-1 to inhibit inflammatory and neuropathic …
Magnetic resonance spectroscopy (MRS) can identify painful lumbar discs and may facilitate improved clinical outcomes of lumbar surgeries for discogenic pain
MG Gornet, J Peacock, J Claude, FW Schranck… - European Spine …, 2019 - Springer
Purpose The goal of this study was to refine clinical MRS to optimize performance and then
determine whether MRS-derived biomarkers reliably identify painful discs, quantify …
determine whether MRS-derived biomarkers reliably identify painful discs, quantify …