Conditioned place preference (CPP) continues to be one of the most popular models to
study the motivational effects of drugs and non‐drug treatments in experimental animals …

The interaction of drugs with biologic targets is a critical area of research, particularly for the
development of medications to treat substance use disorders. In addition to understanding …

Sensation/novelty-seeking is amongst the best markers of cocaine addiction in humans.
However, its implication in the vulnerability to cocaine addiction is still a matter of debate, as …

Carbohydrates are important macronutrients in human and rodent diet patterns that play a
key role in crucial metabolic pathways and provide the necessary energy for proper body …

There are a number of traits that are thought to increase susceptibility to addiction, and some
of these are modeled in preclinical studies. For example,“sensation-seeking” is predictive of …

In humans, exposure to early life stress (ELS) is an established risk factor for the
development of substance use disorders (SUDs) during later life. Similarly, rodents exposed …

Trace amine-associated receptor 1 (TAAR1) is a G protein-coupled receptor that has
recently been implicated in several psychiatric conditions related to monoaminergic …

The present study investigated the consequences of environmental enrichment on the
impact of novelty and motivational properties of ethanol in spontaneously hypertensive rats …

Novelty seeking (NS), defined as a tendency to pursue novel and intense emotional
sensations and experiences, is one of the most relevant individual factors predicting drug …

Maternal deprivation has been shown to increase vulnerability to morphine dependence
and to disturb the enkephalinergic system in adulthood. To study whether or not this …