The present article summarizes recent developments in the characterization of genetic
predisposition to colorectal cancer (CRC). The main themes covered include new hereditary …

Homologous recombination (HR) is a highly conserved DNA repair mechanism that protects
cells from exogenous and endogenous DNA damage. Breast cancer 1 (BRCA1) and breast …

The development of genome-wide massively parallel sequencing, ie, whole-genome and
whole-exome sequencing, and copy number approaches has raised high expectations for …

Purpose Few and small studies have been reported about multigene testing usage by
massively parallel sequencing in European cancer families. There is an open debate about …

Accurate and complete genome duplication is crucial to maintain cell survival and prevent
malignant transformation. The Fanconi anemia (FA) pathway has traditionally been …

Background: Colorectal cancer (CRC) incidence is rising worldwide, as well as in the
Republic of Kazakhstan, while its occurrence is also increasing in the younger population …

The current understanding of the inherited risk of colorectal cancer (CRC) started with an
observational clinical era in the late 19th century, which was followed by a genetic era …

Ferroptosis, a newly discovered way of cell death, has been proved to be involved in the
oncogenesis and development of cancers, including colorectal cancer (CRC). Here, through …

In the past two decades, multiple studies have been undertaken to elucidate the genetic
cause of the predisposition to mismatch repair (MMR)-proficient nonpolyposis colorectal …

Growing evidence has revealed that the E2F family of transcription factor 2 (E2F2)
participates in the tumorigenesis and progression of various tumors, but its role in colorectal …