Familial colorectal cancer Type X (FCCTX) comprises a heterogeneous group of families
with an increased risk of developing colorectal cancer and other related tumors, but with …

Colorectal cancer (CRC) is the third most commonly diagnosed malignancy and has the
second highest mortality rate globally. Thanks to the advent of next-generation sequencing …

Inflammasomes contribute to colorectal cancer signaling by primarily inducing inflammation
in the surrounding tumor microenvironment. Its role in inflammation is receiving increasing …

Macrophages are among the most abundant cells of the tumor microenvironment in head
and neck squamous cancer (HNSC). Although the marker gene sets of macrophages have …

Abstract Background Approximately 5–10% of breast carcinomas have been related to
hereditary conditions and are attributable to pathogenic variants in the BRCA1 and BRCA2 …

Background Germline pathogenic variants are estimated to affect 3–5% of patients with
renal cell carcinoma (RCC). The identification of patients with hereditary RCC is important …

Cases of more than three primary cancers are very rare. This study analyzed the genetic
susceptibility of gene polymorphisms in three patients with multiple primary malignant …

To discover novel high-penetrant risk loci for hereditary colorectal cancer (hCRC) and
polyposis syndromes many whole-exome and whole-genome sequencing (WES/WGS) …

Along with early-onset cancers, multiple primary cancers (MPCs) are likely resulting from
increased genetic susceptibility; however, the associated predisposition genes or …

Rare germline copy number variants in colorectal cancer predisposition characterized by exome
sequencing analysis Rare germline copy number variants in colorectal cancer predisposition …