Dendritic cells (DCs) possess the ability to integrate information about their environment and
communicate it to other leukocytes, shaping adaptive and innate immunity. Over the years, a …

Radiotherapy (RT) is used routinely as a standard treatment for more than 50% of patients
with malignant tumors. The abscopal effect induced by local RT, which is considered as a …

Dendritic cells (DCs) are central regulators of the adaptive immune response, and as such
are necessary for T-cell-mediated cancer immunity. In particular, antitumoral responses …

How neoplastic cells respond to therapy is not solely dependent on the complexity of the
genomic aberrations they harbor but is also regulated by numerous dynamic properties of …

Dendritic cells (DCs) are key orchestrators of immune responses. A specific DC subset,
conventional type 1 DCs (cDC1s), has been recently associated with human cancer patient …

Cytotoxic therapies, besides directly inducing cancer cell death, can stimulate immune-
dependent tumor growth control or paradoxically accelerate tumor progression. The …

Dying cells have an important role in the initiation of CD8+ T cell-mediated immunity. The
cross-presentation of antigens derived from dying cells enables dendritic cells to present …

For decades, lactate has been considered an innocuous bystander metabolite of cellular
metabolism. However, emerging studies show that lactate acts as a complex …

In many settings, tumor-associated inflammation, supported mainly by innate immune cells,
contributes to tumor growth. Initial innate activation triggers secretion of inflammatory …

It is known that interactions between nociceptors and dendritic cells (DCs) can modulate
immune responses in barrier tissues. However, our understanding of the underlying …