Insights into the Mechanisms of Action of Akkermansia muciniphila in the Treatment of Non-Communicable Diseases

H Mruk-Mazurkiewicz, M Kulaszyńska, W Czarnecka… - Nutrients, 2024 - mdpi.com
This comprehensive review delineates the extensive roles of Akkermansia muciniphila in
various health domains, spanning from metabolic and inflammatory diseases to …

Function and therapeutic prospects of next-generation probiotic Akkermansia muciniphila in infectious diseases

L Li, M Li, Y Chen, Z Yu, P Cheng, Z Yu… - Frontiers in …, 2024 - frontiersin.org
Akkermansia muciniphila is a gram-negative bacterium that colonizes the human gut,
making up 3–5% of the human microbiome. A. muciniphila is a promising next-generation …

Akkermansia muciniphila - friend or foe in colorectal cancer?

EO Gubernatorova, EA Gorshkova… - Frontiers in …, 2023 - frontiersin.org
Akkermansia muciniphila is a gram-negative anaerobic bacterium, which represents a part
of the commensal human microbiota. Decline in the abundance of A. muciniphila among …

Paeoniflorin confers ferroptosis resistance by regulating the gut microbiota and its metabolites in diabetic cardiomyopathy

H Wu, P Zhang, J Zhou, S Hu, J Hao… - … of Physiology-Cell …, 2024 - journals.physiology.org
Diabetic cardiomyopathy (DCM) is closely related to ferroptosis, a new type of cell death that
mainly manifests as intracellular iron accumulation and lipid peroxidation. Paeoniflorin (PA) …

Gynostemma pentaphyllum Extract Alleviates NASH in Mice: Exploration of Inflammation and Gut Microbiota

FY Jiang, SR Yue, YY Tan, N Tang, YS Xu, BJ Zhang… - Nutrients, 2024 - mdpi.com
NASH (non-alcoholic steatohepatitis) is a severe liver disease characterized by hepatic
chronic inflammation that can be associated with the gut microbiota. In this study, we …

Bacillus halotolerans attenuates inflammation induced by enterotoxigenic Escherichia coli infection in vivo and in vitro based on its metabolite soyasaponin I …

M Li, D Zhao, J Meng, T Pan, J Li, J Guo, H Huang… - Food & Function, 2024 - pubs.rsc.org
Soyasaponins, recognized for their anti-inflammatory and antioxidant effects, have not yet
been fully explored for their role in combating enterotoxigenic Escherichia coli (ETEC) …

Akkermansia muciniphila in infectious disease: A new target for this next-generation probiotic?

JM Keane, M Cazzaniga, CGM Gahan - Science Progress, 2024 - journals.sagepub.com
The common gastrointestinal commensal Akkermansia muciniphila is a mucin-degrading
bacterium that is greatly reduced in individuals consuming a high-fat diet. Increasing …

Akkermansia muciniphila derived tripeptide jams the gear of sepsis, inflammation and mortality

PD Cani, M Van Hul, R Bachmann - Gut, 2024 - gut.bmj.com
Sepsis constitutes a global burden on medical care and accounts for nearly 20% of reported
global mortality. 1 The development of sepsis is complex, though the triggering of a …

Toll‐like receptors in health and disease

K Wang, H Huang, Q Zhan, H Ding, Y Li - MedComm, 2024 - Wiley Online Library
Toll‐like receptors (TLRs) are inflammatory triggers and belong to a family of pattern
recognition receptors (PRRs) that are central to the regulation of host protective adaptive …

LCN2 and ELANE overexpression induces sepsis

T Wang, JG Han, W Dong, YH Yu - Medicine, 2024 - journals.lww.com
Sepsis is a syndrome characterized by a systemic inflammatory response due to the
invasion of pathogenic microorganisms. The relationship between Lipocalin-2 (LCN2) …