[HTML][HTML] Cocrystals by design: a rational coformer selection approach for tackling the API problems

M Singh, H Barua, VGSS Jyothi, MR Dhondale… - Pharmaceutics, 2023 - mdpi.com
Active pharmaceutical ingredients (API) with unfavorable physicochemical properties and
stability present a significant challenge during their processing into final dosage forms …

[HTML][HTML] Recent advances in co-former screening and formation prediction of multicomponent solid forms of low molecular weight drugs

Y Deng, S Liu, Y Jiang, ICB Martins, T Rades - Pharmaceutics, 2023 - mdpi.com
Multicomponent solid forms of low molecular weight drugs, such as co-crystals, salts, and co-
amorphous systems, are a result of the combination of an active pharmaceutical ingredient …

[HTML][HTML] Virtual Screening, Structural Analysis, and Formation Thermodynamics of Carbamazepine Cocrystals

AO Surov, AG Ramazanova, AP Voronin, KV Drozd… - Pharmaceutics, 2023 - mdpi.com
In this study, the existing set of carbamazepine (CBZ) cocrystals was extended through the
successful combination of the drug with the positional isomers of acetamidobenzoic acid …

In silico co-crystal design: assessment of the latest advances

C von Essen, D Luedeker - Drug Discovery Today, 2023 - Elsevier
Pharmaceutical co-crystals represent a growing class of crystal forms in the context of
pharmaceutical science. They are attractive to pharmaceutical scientists because they …

[HTML][HTML] Cocrystals and drug–drug cocrystals of anticancer drugs: A perception towards screening techniques, preparation, and enhancement of drug properties

DD Kara, M Rathnanand - Crystals, 2022 - mdpi.com
The most favored approach for drug administration is the oral route. Several anticancer
drugs come under this category and mostly lack solubility and oral bioavailability, which are …

Exploring the cocrystal landscape of posaconazole by combining high-throughput screening experimentation with computational chemistry

M Guidetti, R Hilfiker, M Kuentz… - Crystal Growth & …, 2022 - ACS Publications
The development of multicomponent crystal forms, such as cocrystals, represents a means
to enhance the dissolution and absorption properties of poorly water-soluble drug …

[HTML][HTML] Cocrystals of tuberculosis antibiotics: Challenges and missed opportunities

E Khanfar, S Nagy, A Széchenyi - International journal of pharmaceutics, 2022 - Elsevier
Cocrystals have been extensively used to improve the physicochemical properties and
bioavailability of active pharmaceutical ingredients. Cocrystals of anti-tuberculosis …

Machine Learning-Guided Prediction of Cocrystals Using Point Cloud-Based Molecular Representation

S Ahmadi, MA Ghanavati, S Rohani - Chemistry of Materials, 2024 - ACS Publications
The design and synthesis of cocrystals have emerged as promising crystal engineering
strategies for enhancing the physicochemical properties of a diverse range of target …

[HTML][HTML] Cocrystal prediction of bexarotene by graph convolution network and bioavailability improvement

F Xiao, Y Cheng, JR Wang, D Wang, Y Zhang, K Chen… - Pharmaceutics, 2022 - mdpi.com
Bexarotene (BEX) was approved by the FDA in 1999 for the treatment of cutaneous T-cell
lymphoma (CTCL). The poor aqueous solubility causes the low bioavailability of the drug …

In-silico aided screening and characterization results in stability enhanced novel roxadustat co-crystal

AR Muthusamy, A Singh, MSS Sundaram… - Journal of …, 2024 - Elsevier
Roxadustat (RXD) is an approved drug substances for the treatment of renal anemia. It has
poor aqueous solubility and photochemical stability. This study employs a comprehensive …