[HTML][HTML] Cocrystals by design: a rational coformer selection approach for tackling the API problems
Active pharmaceutical ingredients (API) with unfavorable physicochemical properties and
stability present a significant challenge during their processing into final dosage forms …
stability present a significant challenge during their processing into final dosage forms …
[HTML][HTML] Recent advances in co-former screening and formation prediction of multicomponent solid forms of low molecular weight drugs
Multicomponent solid forms of low molecular weight drugs, such as co-crystals, salts, and co-
amorphous systems, are a result of the combination of an active pharmaceutical ingredient …
amorphous systems, are a result of the combination of an active pharmaceutical ingredient …
[HTML][HTML] Virtual Screening, Structural Analysis, and Formation Thermodynamics of Carbamazepine Cocrystals
In this study, the existing set of carbamazepine (CBZ) cocrystals was extended through the
successful combination of the drug with the positional isomers of acetamidobenzoic acid …
successful combination of the drug with the positional isomers of acetamidobenzoic acid …
In silico co-crystal design: assessment of the latest advances
C von Essen, D Luedeker - Drug Discovery Today, 2023 - Elsevier
Pharmaceutical co-crystals represent a growing class of crystal forms in the context of
pharmaceutical science. They are attractive to pharmaceutical scientists because they …
pharmaceutical science. They are attractive to pharmaceutical scientists because they …
[HTML][HTML] Cocrystals and drug–drug cocrystals of anticancer drugs: A perception towards screening techniques, preparation, and enhancement of drug properties
DD Kara, M Rathnanand - Crystals, 2022 - mdpi.com
The most favored approach for drug administration is the oral route. Several anticancer
drugs come under this category and mostly lack solubility and oral bioavailability, which are …
drugs come under this category and mostly lack solubility and oral bioavailability, which are …
Exploring the cocrystal landscape of posaconazole by combining high-throughput screening experimentation with computational chemistry
M Guidetti, R Hilfiker, M Kuentz… - Crystal Growth & …, 2022 - ACS Publications
The development of multicomponent crystal forms, such as cocrystals, represents a means
to enhance the dissolution and absorption properties of poorly water-soluble drug …
to enhance the dissolution and absorption properties of poorly water-soluble drug …
[HTML][HTML] Cocrystals of tuberculosis antibiotics: Challenges and missed opportunities
E Khanfar, S Nagy, A Széchenyi - International journal of pharmaceutics, 2022 - Elsevier
Cocrystals have been extensively used to improve the physicochemical properties and
bioavailability of active pharmaceutical ingredients. Cocrystals of anti-tuberculosis …
bioavailability of active pharmaceutical ingredients. Cocrystals of anti-tuberculosis …
Machine Learning-Guided Prediction of Cocrystals Using Point Cloud-Based Molecular Representation
The design and synthesis of cocrystals have emerged as promising crystal engineering
strategies for enhancing the physicochemical properties of a diverse range of target …
strategies for enhancing the physicochemical properties of a diverse range of target …
[HTML][HTML] Cocrystal prediction of bexarotene by graph convolution network and bioavailability improvement
F Xiao, Y Cheng, JR Wang, D Wang, Y Zhang, K Chen… - Pharmaceutics, 2022 - mdpi.com
Bexarotene (BEX) was approved by the FDA in 1999 for the treatment of cutaneous T-cell
lymphoma (CTCL). The poor aqueous solubility causes the low bioavailability of the drug …
lymphoma (CTCL). The poor aqueous solubility causes the low bioavailability of the drug …
In-silico aided screening and characterization results in stability enhanced novel roxadustat co-crystal
AR Muthusamy, A Singh, MSS Sundaram… - Journal of …, 2024 - Elsevier
Roxadustat (RXD) is an approved drug substances for the treatment of renal anemia. It has
poor aqueous solubility and photochemical stability. This study employs a comprehensive …
poor aqueous solubility and photochemical stability. This study employs a comprehensive …