Our previous International Union of Basic and Clinical Pharmacology report on the
nomenclature and classification of adenosine receptors (2011) contained a number of …

This review discusses the evidence supporting a role for ATP signaling (operated by P 2 X
and P 2 Y receptors) and adenosine signaling (mainly operated by A 1 and A 2A receptors) …

Dysfunction of goal-directed behaviors under stressful or pathological conditions results in
impaired decision-making and loss of flexibility of thoughts and behaviors, which underlie …

Adenosine, acting both through G-protein coupled adenosine receptors and intracellularly,
plays a complex role in multiple physiological and pathophysiological processes by …

Depressive conditions precipitated by repeated stress are a major socio-economical burden
in Western countries. Previous studies showed that ATP-P2X7 receptors (P2X7R) and …

Major depressive disorder (MDD) is the foremost cause of global disability, being
responsible for enormous personal, societal, and economical costs. Importantly, existing …

Essential tremor (ET) is one of the most common neurological disorders that often affects
people in the prime of their lives, leading to a significant reduction in their quality of life …

Adenosine and dopamine interact antagonistically in living mammals. These interactions are
mediated via adenosine A2A and dopamine D2 receptors (R). Stimulation of A2AR inhibits …

Parkinson's disease (PD) is a neurodegenerative condition characterized by the loss of
dopaminergic neurons in the substantia nigra pars compacta (SNpc) in the midbrain …

Huntington's disease (HD) is a neurodegenerative disorder, characterized by motor
dysfunction, psychiatric disturbance, and cognitive decline. In the early stage of HD, occurs a …