[HTML][HTML] Knife's edge: Balancing immunogenicity and reactogenicity in mRNA vaccines
Since the discovery of messenger RNA (mRNA), there have been tremendous efforts to
wield them in the development of therapeutics and vaccines. During the COVID-19 …
wield them in the development of therapeutics and vaccines. During the COVID-19 …
[HTML][HTML] Outlook of pandemic preparedness in a post-COVID-19 world
BA Williams, CH Jones, V Welch, JM True - npj Vaccines, 2023 - nature.com
The COVID-19 pandemic was met with rapid, unprecedented global collaboration and
action. Even still, the public health, societal, and economic impact may be felt for years to …
action. Even still, the public health, societal, and economic impact may be felt for years to …
[HTML][HTML] N1-methylpseudouridylation of mRNA causes +1 ribosomal frameshifting
In vitro-transcribed (IVT) mRNAs are modalities that can combat human disease, exemplified
by their use as vaccines for severe acute respiratory syndrome coronavirus 2 (SARS-CoV …
by their use as vaccines for severe acute respiratory syndrome coronavirus 2 (SARS-CoV …
Ionizable lipid nanoparticles deliver mRNA to pancreatic β cells via macrophage-mediated gene transfer
Systemic messenger RNA (mRNA) delivery to organs outside the liver, spleen, and lungs
remains challenging. To overcome this issue, we hypothesized that altering nanoparticle …
remains challenging. To overcome this issue, we hypothesized that altering nanoparticle …
[HTML][HTML] Molecular fate-mapping of serum antibody responses to repeat immunization
A Schiepers, MFL van't Wout, AJ Greaney, T Zang… - Nature, 2023 - nature.com
The protective efficacy of serum antibodies results from the interplay of antigen-specific B
cell clones of different affinities and specificities. These cellular dynamics underlie serum …
cell clones of different affinities and specificities. These cellular dynamics underlie serum …
Single immunizations of self-amplifying or non-replicating mRNA-LNP vaccines control HPV-associated tumors in mice
J Ramos da Silva, K Bitencourt Rodrigues… - Science Translational …, 2023 - science.org
As mRNA vaccines have proved to be very successful in battling the coronavirus disease
2019 (COVID-19) pandemic, this new modality has attracted widespread interest for the …
2019 (COVID-19) pandemic, this new modality has attracted widespread interest for the …
[HTML][HTML] Lyophilization provides long-term stability for a lipid nanoparticle-formulated, nucleoside-modified mRNA vaccine
Lipid nanoparticle (LNP)-formulated nucleoside-modified mRNA vaccines have proven to be
very successful in the fight against the coronavirus disease 2019 (COVID-19) pandemic …
very successful in the fight against the coronavirus disease 2019 (COVID-19) pandemic …
Assessment of a quadrivalent nucleoside-modified mRNA vaccine that protects against group 2 influenza viruses
M McMahon, G O'Dell, J Tan… - Proceedings of the …, 2022 - National Acad Sciences
Combined vaccine formulations targeting not only hemagglutinin but also other influenza
virus antigens could form the basis for a universal influenza virus vaccine that has the …
virus antigens could form the basis for a universal influenza virus vaccine that has the …
Assessment of three‐dimensional RNA structure prediction in CASP15
The prediction of RNA three‐dimensional structures remains an unsolved problem. Here, we
report assessments of RNA structure predictions in CASP15, the first CASP exercise that …
report assessments of RNA structure predictions in CASP15, the first CASP exercise that …
Use of a liver-targeting immune-tolerogenic mRNA lipid nanoparticle platform to treat peanut-induced anaphylaxis by single-and multiple-epitope nucleotide …
While oral desensitization is capable of alleviating peanut allergen anaphylaxis, long-term
immune tolerance is the sought-after goal. We developed a liver-targeting lipid nanoparticle …
immune tolerance is the sought-after goal. We developed a liver-targeting lipid nanoparticle …