Owing to the dysregulation of protein kinase activity in many diseases including cancer, this
enzyme family has become one of the most important drug targets in the 21 st century. There …

Pyrazole derivatives, as a class of heterocyclic compounds, possess unique chemical
structures that confer them with a broad spectrum of pharmacological activities. They have …

Pyrazole, characterized by a five-membered heterocyclic structure featuring two neighboring
nitrogen atoms, serves as a core element. Pyrazoles hold a privileged status as versatile …

Cancer, a noncommunicable disease, is the leading cause of mortality worldwide and is
anticipated to rise by 75% in the next two decades, reaching approximately 25 million cases …

Pyrazole, as a small molecule, was discovered for higher cytotoxicity and affinity towards
Aurora-A kinase. Based on these facts, a novel pyrazole substituted at the 4 th position was …

In this study, we synthesized a number of new intriguing azoles bearing nicotinoyl moiety,
their antimicrobial and antitumor activities were investigated as well. We succeeded to …

Aminopyrazoles represent interesting structures in medicinal chemistry, and several
derivatives showed biological activity in different therapeutic areas. Previously reported 5 …

Abstract Background Human Epidermal Growth Factor Receptor-2 (HER2), a
transmembrane tyrosine kinase receptor, has been associated with several types of cancer …

The eradication of multifactorial diseases, such as cancer, requires the design of drug
candidates that attack multiple targets that contribute to the progression and proliferation of …

This study aims to comprehensively characterize 576 inhibitors targeting Spleen Tyrosine
Kinase (SYK), a non-receptor tyrosine kinase primarily found in haematopoietic cells, with …