Variation in the levels of distress in women at increased risk of breast cancer has been
reported, yet there is limited understanding of the factors that are associated with heightened …

Since the late 1980s, in France and in a number of other countries, cancer genetics testing
has become a clinical reality, particularly for hereditary breast and ovarian cancer. BRCA …

Background: Hereditary non‐polyposis colorectal cancer (HNPCC) is an inherited genetic
condition associated with microsatellite instability; it accounts for around 5 per cent of all …

Objective: The purpose of this study was to determine whether women with a family history
of ovarian cancer are at reduced risk of ovarian cancer from the use of oral contraceptives …

Background. In response to increased referrals to geneticists and the predicted patient
demand for genetic counselling, it has been proposed that some genetics services should …

Traditionally genetic counselling has promoted a non‐directive approach to patients'
decision‐making but the feasibility of this has been questioned. Unlike most branches of …

Objectives. The aim of this study was to investigate the appropriateness of primary care
referrals to the Oxford Regional Genetics Service on account of a family history of breast …

Objectives: Several cancers show the tendency to aggregate in families. But the contribution
of heredity to the causation of sporadic malignancies, like cervical cancer is unclear. Study …

Currently there is much debate regarding the ability of mathematical models incorporating
epidemiological information or mutation-based risk algorithms to accurately predict a …

INTRODUCTION: The value of special screening for women at moderate breast cancer risk
with a family history of breast cancer remains controversial. Little is known about recall rates …