Integrins, and integrin-mediated adhesions, have long been recognized to provide the main
molecular link attaching cells to the extracellular matrix (ECM) and to serve as bidirectional …

Cells can detect and react to the biophysical properties of the extracellular environment
through integrin-based adhesion sites and adapt to the extracellular milieu in a process …

Cells exert, sense, and respond to physical forces through an astounding diversity of
mechanisms. Here we review recently developed tools to quantify the forces generated by …

Our incomplete understanding of osteoarthritis (OA) pathogenesis has significantly hindered
the development of disease-modifying therapy. The functional relationship between …

Highlights•Physical cues from the tumor microenvironment strongly affect cancer cell
behavior.•Novel techniques increasingly help to capture those cues in vitro.•Mechanisms for …

Forces generated by cells are critical regulators of cell adhesion, signaling, and function,
and they are also essential drivers in the morphogenetic events of development. Over the …

Evidence from physical sciences in oncology increasingly suggests that the interplay
between the biophysical tumor microenvironment and genetic regulation has significant …

During cell migration, the forces generated in the actin cytoskeleton are transmitted across
transmembrane receptors to the extracellular matrix or other cells through a series of …

The linkage of cells to their microenvironment is mediated by a series of bonds that
dynamically engage and disengage, in what has been conceptualized as the molecular …

Acting as a bridge between the cytoskeleton of the cell and the extra cellular matrix (ECM),
the cell-ECM adhesions with integrins at their core, play a major role in cell signalling to …