Tau PET correlates with different Alzheimer's disease‐related features compared to CSF and plasma p‐tau biomarkers
R Ossenkoppele, J Reimand, R Smith… - EMBO molecular …, 2021 - embopress.org
PET, CSF and plasma biomarkers of tau pathology may be differentially associated with
Alzheimer's disease (AD)‐related demographic, cognitive, genetic and neuroimaging …
Alzheimer's disease (AD)‐related demographic, cognitive, genetic and neuroimaging …
[HTML][HTML] Gene-SGAN: discovering disease subtypes with imaging and genetic signatures via multi-view weakly-supervised deep clustering
Disease heterogeneity has been a critical challenge for precision diagnosis and treatment,
especially in neurologic and neuropsychiatric diseases. Many diseases can display multiple …
especially in neurologic and neuropsychiatric diseases. Many diseases can display multiple …
Robustly uncovering the heterogeneity of neurodegenerative disease by using data-driven subtyping in neuroimaging: A review
Neurodegenerative diseases are associated with heterogeneity in genetics, pathology, and
clinical manifestation. Understanding this heterogeneity is particularly relevant for clinical …
clinical manifestation. Understanding this heterogeneity is particularly relevant for clinical …
[HTML][HTML] Data-driven FDG-PET subtypes of Alzheimer's disease-related neurodegeneration
Background Previous research has described distinct subtypes of Alzheimer's disease (AD)
based on the differences in regional patterns of brain atrophy on MRI. We conducted a data …
based on the differences in regional patterns of brain atrophy on MRI. We conducted a data …
Cognitive domain harmonization and cocalibration in studies of older adults.
Objective: Studies use different instruments to measure cognitirating cognitive tests permit
direct comparisons of individuals across studies and pooling data for joint analyses. Method …
direct comparisons of individuals across studies and pooling data for joint analyses. Method …
Personalized brain models identify neurotransmitter receptor changes in Alzheimer's disease
Alzheimer's disease involves many neurobiological alterations from molecular to
macroscopic spatial scales, but we currently lack integrative, mechanistic brain models …
macroscopic spatial scales, but we currently lack integrative, mechanistic brain models …
Multi-scale semi-supervised clustering of brain images: Deriving disease subtypes
Disease heterogeneity is a significant obstacle to understanding pathological processes and
delivering precision diagnostics and treatment. Clustering methods have gained popularity …
delivering precision diagnostics and treatment. Clustering methods have gained popularity …
[HTML][HTML] Dissociation of tau pathology and neuronal hypometabolism within the ATN framework of Alzheimer's disease
Alzheimer's disease (AD) is defined by amyloid (A) and tau (T) pathologies, with T better
correlated to neurodegeneration (N). However, T and N have complex regional relationships …
correlated to neurodegeneration (N). However, T and N have complex regional relationships …
[HTML][HTML] Combining tau-PET and fMRI meta-analyses for patient-centered prediction of cognitive decline in Alzheimer's disease
Background Tau-PET is a prognostic marker for cognitive decline in Alzheimer's disease,
and the heterogeneity of tau-PET patterns matches cognitive symptom heterogeneity. Thus …
and the heterogeneity of tau-PET patterns matches cognitive symptom heterogeneity. Thus …
[HTML][HTML] Differential associations of APOE-ε2 and APOE-ε4 alleles with PET-measured amyloid-β and tau deposition in older individuals without dementia
Purpose To examine associations between the APOE-ε2 and APOE-ε4 alleles and core
Alzheimer's disease (AD) pathological hallmarks as measured by amyloid-β (Aβ) and tau …
Alzheimer's disease (AD) pathological hallmarks as measured by amyloid-β (Aβ) and tau …