[HTML][HTML] In vitro and ex vivo models in inhalation biopharmaceutical research—advances, challenges and future perspectives
Oral inhalation results in pulmonary drug targeting and thereby reduces systemic side
effects, making it the preferred means of drug delivery for the treatment of respiratory …
effects, making it the preferred means of drug delivery for the treatment of respiratory …
Recent advances in human respiratory epithelium models for drug discovery
The respiratory epithelium is intimately associated with the pathophysiologies of highly
infectious viral contagions and chronic illnesses such as chronic obstructive pulmonary …
infectious viral contagions and chronic illnesses such as chronic obstructive pulmonary …
Correlation and clinical relevance of animal models for inhaled pharmaceuticals and biopharmaceuticals
T Sécher, E Bodier-Montagutelli, A Guillon… - Advanced drug delivery …, 2020 - Elsevier
Nonclinical studies are fundamental for the development of inhaled drugs, as for any drug
product, and for successful translation to clinical practice. They include in silico, in vitro, ex …
product, and for successful translation to clinical practice. They include in silico, in vitro, ex …
[HTML][HTML] In Vitro to ex Vivo/In Vivo Correlation (IVIVC) of dissolution kinetics from inhaled particulate solutes using air/blood barrier models: Relation between in vitro …
P Gerde, M Malmlöf, E Selg - Journal of Aerosol Science, 2021 - Elsevier
Correlating data from in vitro dissolution testing of inhaled particulate pharmaceuticals or air
pollutants with the dissolution and distribution to the blood circulation of the same aerosols …
pollutants with the dissolution and distribution to the blood circulation of the same aerosols …
[HTML][HTML] Applying design of experiments (DoE) on the properties of buccal film for nicotine delivery
J Suksaeree, B Chaichawawut, M Srichan… - e-Polymers, 2021 - degruyter.com
Abstract Design of experiments is used to optimize ratios between deproteinized natural
rubber latex, Eudragit® NM 30 D, and pectin for nicotine buccal film with dependent …
rubber latex, Eudragit® NM 30 D, and pectin for nicotine buccal film with dependent …
Fundamentals and Applications of Isolated Perfused Lung (IPL) Model in the Development of Pulmonary Drug Delivery
K Mireskandari, YH Ardakani… - Current Drug …, 2023 - ingentaconnect.com
Estimating parameters such as pulmonary drug disposition and deposited dose, as well as
determining the influence of pulmonary pharmacokinetics (PK) on drug efficacy and safety …
determining the influence of pulmonary pharmacokinetics (PK) on drug efficacy and safety …
[图书][B] Dissolvit: Development and Validation of a New in Vitro Dissolution Apparatus for Dry Powder Aerosols
M Malmlöf - 2022 - search.proquest.com
Today there are no recommended dissolution methods for use in the development of
newinhalable drugs. In the absence of such tailored methods, standard dissolution test …
newinhalable drugs. In the absence of such tailored methods, standard dissolution test …