Integrating fish models in tuberculosis vaccine development

AK Saralahti, MIE Uusi-Mäkelä… - Disease Models & …, 2020 - journals.biologists.com
Tuberculosis is a chronic infection by Mycobacterium tuberculosis that results in over 1.5
million deaths worldwide each year. Currently, there is only one vaccine against …

Host-directed therapeutics against mycobacterial infections

H Tomioka, C Sano, Y Tatano - Current Pharmaceutical Design, 2017 - ingentaconnect.com
The high incidence of tuberculosis (TB) in the world, especially in developing countries, the
resurgence of TB in industrialized countries, and the global increase in the prevalence of …

[HTML][HTML] Mycobacterial response to organic solvents and possible implications on cross-resistance with antimicrobial agents

C Pacífico, P Fernandes… - Frontiers in …, 2018 - frontiersin.org
Mycobacterium vaccae, a bacterium found in soil, has been receiving attention as adjuvant
to antituberculosis treatment, vaccines and immunotherapies and even as antidepressant …

Prevalence and clinical outcomes of nontuberculous mycobacteria in a Brazilian cystic fibrosis reference center

TB Aiello, CE Levy, TR Zaccariotto… - Pathogens and …, 2018 - academic.oup.com
Nontuberculous mycobacteria (NTM) have been well established as an opportunistic
pathogenic bacterial group for cystic fibrosis (CF) patients, with a prevalence ranging from …

Mycobacterium tuberculosis Rv2005c Induces Dendritic Cell Maturation and Th1 Responses and Exhibits Immunotherapeutic Activity by Fusion with the Rv2882c …

YW Back, KW Shin, S Choi, HS Park, KI Lee, HG Choi… - Vaccines, 2020 - mdpi.com
Immunotherapy represents a promising approach for improving current antibiotic treatments
through the engagement of the host's immune system. Latency-associated antigens have …

Mycobacterium vaccae Nebulization Can Protect against Asthma in Balb/c Mice by Regulating Th9 Expression

C Li, X Jiang, M Luo, G Feng, Q Sun, Y Chen - PloS one, 2016 - journals.plos.org
Asthma is a heterogeneous disease characterized by chronic airway inflammation. CD4 (+)
T-helper 9 (Th9) cells are closely linked to asthma, helping to regulate inflammation and …

Immunotherapy for TB

TM Doherty - Immunotherapy, 2012 - Future Medicine
Mycobacterium tuberculosis was one of the first human pathogens to be identified as the
cause of a specific disease–TB. TB was also one of the first specific diseases for which …

[HTML][HTML] Optimizing antigen selection for the development of tuberculosis vaccines

Y Yang, YZ Chen, T Xia - Cell Insight, 2024 - Elsevier
Tuberculosis (TB) remains a prevalent global infectious disease caused by genetically
closely related tubercle bacilli in Mycobacterium tuberculosis complex (MTBC). For a …

Inhalation of nebulized Mycobacterium vaccae can protect against allergic bronchial asthma in mice by regulating the TGF-β/Smad signal transduction pathway

X Jiang, C Li, G Feng, M Luo, Q Sun - Allergy, Asthma & Clinical …, 2020 - Springer
Background Mycobacterium vaccae nebulization imparted protective effect against allergic
asthma in a mouse model. The TGF-β/Smad signal transduction pathway plays an important …

A new TB vaccine: Fact or fiction?

PD van Helden, EG Hoal - Comparative Immunology, Microbiology and …, 2013 - Elsevier
Vaccination has been spectacularly successful in eradicating or controlling some infectious
diseases, and is particularly attractive as an approach to tackling other infectious diseases …