Transforming growth factor-β (TGFβ) is a ubiquitous cytokine essential for embryonic
development and postnatal tissue homeostasis. TGFβ signalling regulates several biological …

The transcription factor c‐Jun regulates the expression of genes involved in proliferation and
inflammation in many cell types but its role in human renal disease is largely unclear. In the …

The pathogenesis of hyperuricemia-induced chronic kidney disease is largely unknown. In
this study, we investigated whether extracellular signal–regulated kinases1/2 (ERK1/2) …

Chronic inflammation is a major outcome determinant in several renal disorders. Induction of
monocyte chemoattractant protein (MCP)-1 expression in tubular epithelial cells contributes …

Kidney injury molecule-1 (Kim-1) is associated with ischemic and proteinuric tubular injury;
however, whether dysregulation of the renin-angiotensin system (RAS) can also induce Kim …

Abstract Aquaporin-3 (AQP3), a transporter of water, glycerol and H 2 O 2, is expressed in
basolateral membranes of principal cells in kidney collecting duct. Here, we report that …

During renal injury, activation of p38 mitogen-activated protein kinase (MAPK) in proximal
tubular cells plays an important role in the inflammatory events that eventually lead to renal …

We recently reported that necrotic renal proximal epithelial cells (RPTC) stimulate the
expression of P2X7 receptor in renal fibroblasts and that P2X7 receptor mediates …

Regulation of protein kinase activities is crucial in both physiology and disease, but analysis
is hampered by the multitude and complexity of kinase networks. We used novel peptide …

Guggulsterone derivatives were prepared using [3+ 2] click chemistry with aryl and alkyl
acetylene. The series of derivatives were evaluated for their cellular protective effects on …