Targeting NF-κB pathway for the therapy of diseases: mechanism and clinical study
H Yu, L Lin, Z Zhang, H Zhang, H Hu - Signal transduction and targeted …, 2020 - nature.com
NF-κB pathway consists of canonical and non-canonical pathways. The canonical NF-κB is
activated by various stimuli, transducing a quick but transient transcriptional activity, to …
activated by various stimuli, transducing a quick but transient transcriptional activity, to …
The non-canonical NF-κB pathway in immunity and inflammation
SC Sun - Nature reviews immunology, 2017 - nature.com
The nuclear factor-κB (NF-κB) family of transcription factors is activated by canonical and
non-canonical signalling pathways, which differ in both signalling components and …
non-canonical signalling pathways, which differ in both signalling components and …
A genome-scale screen for synthetic drivers of T cell proliferation
The engineering of autologous patient T cells for adoptive cell therapies has revolutionized
the treatment of several types of cancer. However, further improvements are needed to …
the treatment of several types of cancer. However, further improvements are needed to …
Signaling via the NFκB system
The nuclear factor kappa B (NFκB) family of transcription factors is a key regulator of immune
development, immune responses, inflammation, and cancer. The NFκB signaling system …
development, immune responses, inflammation, and cancer. The NFκB signaling system …
Inhibitory feedback control of NF-κB signalling in health and disease
JA Prescott, JP Mitchell, SJ Cook - Biochemical Journal, 2021 - portlandpress.com
Cells must adapt to changes in their environment to maintain cell, tissue and organismal
integrity in the face of mechanical, chemical or microbiological stress. Nuclear factor-κB (NF …
integrity in the face of mechanical, chemical or microbiological stress. Nuclear factor-κB (NF …
Regulation of NF-κB by TNF family cytokines
The NF-κB family of inducible transcription factors is activated in response to a variety of
stimuli. Amongst the best-characterized inducers of NF-κB are members of the TNF family of …
stimuli. Amongst the best-characterized inducers of NF-κB are members of the TNF family of …
Facilitating T cell infiltration in tumor microenvironment overcomes resistance to PD-L1 blockade
Immune checkpoint blockade therapies fail to induce responses in the majority of cancer
patients, so how to increase the objective response rate becomes an urgent challenge …
patients, so how to increase the objective response rate becomes an urgent challenge …
Specific and nonhepatotoxic degradation of nuclear hepatitis B virus cccDNA
J Lucifora, Y Xia, F Reisinger, K Zhang, D Stadler… - Science, 2014 - science.org
Current antiviral agents can control but not eliminate hepatitis B virus (HBV), because HBV
establishes a stable nuclear covalently closed circular DNA (cccDNA). Interferon-α treatment …
establishes a stable nuclear covalently closed circular DNA (cccDNA). Interferon-α treatment …
NF-κB-independent role of IKKα/IKKβ in preventing RIPK1 kinase-dependent apoptotic and necroptotic cell death during TNF signaling
Y Dondelinger, S Jouan-Lanhouet, T Divert, E Theatre… - Molecular cell, 2015 - cell.com
TNF is a master pro-inflammatory cytokine. Activation of TNFR1 by TNF can result in both
RIPK1-independent apoptosis and RIPK1 kinase-dependent apoptosis or necroptosis …
RIPK1-independent apoptosis and RIPK1 kinase-dependent apoptosis or necroptosis …
Crosstalk of reactive oxygen species and NF-κB signaling
MJ Morgan, Z Liu - Cell research, 2011 - nature.com
NF-κB proteins are a family of transcription factors that are of central importance in
inflammation and immunity. NF-κB also plays important roles in other processes, including …
inflammation and immunity. NF-κB also plays important roles in other processes, including …