Lipofuscin accumulates with age as intracellular fluorescent granules originating from
incomplete lysosomal digestion of phagocytosed and autophagocytosed material. The …

Serotoninergic signaling is identified as a crucial player in psychiatric disorders (notably
depression), presenting it as a significant therapeutic target for treating such conditions …

Cu (II)-catalyzed N-arylation of electron-deficient NH-heterocycles 'in-water'at room
temperature is described. A wide substrate scope with respect to structural and electronic …

Introduction COX-2 is a crucial enzyme in the manufacture of prostaglandins. The enzyme's
metabolites might have an important function as regulators of the inflammatory response …

Background: Cyclooxygenase-2 (COX-2), the key enzyme in the arachidonic acid
conversion to prostaglandins, is one of the enzymes associated with different …

The serious adverse effects caused by non‐selective and selective cyclooxygenase‐2 (COX‐
2) inhibitors remain significant concerns for current anti‐inflammatory drugs. In this study, we …

Objective: To assess the analgesic and anti-inflammatory effects of standardized extract of
Cotinus coggygria (C. coggygria) in different animal models. Methods: C. coggygria extracts …

To develop the new analgesics, different approaches to the modification of 4‐amino‐5‐
phenyl‐3‐(trifluoromethyl) pyrazoles were proposed. A series of 4‐(het) arylimino‐3 …

Inflammation is an essential body immune system response against various infections and
tissue injuries and maintains normal homeostasis. Alterations in inflammatory responses …

The thiazole ring is a unique heterocyclic motif among heterocyclic compounds. This five-
member ring with one nitrogen and one sulphur atom displays a wide array of …