The immune suppressive tumor microenvironment in multiple myeloma: The contribution of myeloid-derived suppressor cells

C Giannotta, F Autino, M Massaia - Frontiers in Immunology, 2023 - frontiersin.org
Myeloid derived suppressors cells (MDSC) play major roles in regulating immune
homeostasis and immune responses in many conditions, including cancer. MDSC interact …

Patient-Derived Multiple Myeloma 3D Models for Personalized Medicine—Are We There Yet?

D Lourenço, R Lopes, C Pestana, AC Queirós… - International Journal of …, 2022 - mdpi.com
Despite the wide variety of existing therapies, multiple myeloma (MM) remains a disease
with dismal prognosis. Choosing the right treatment for each patient remains one of the …

Metformin attenuates multiple myeloma cell proliferation and encourages apoptosis by suppressing METTL3-mediated m6A methylation of THRAP3, RBM25, and …

CJ Chen, JY Huang, JQ Huang, JY Deng… - Cell Cycle, 2023 - Taylor & Francis
Based on the results of epidemiological and preclinical studies, metformin can improve the
prognosis of patients with malignant tumors. Studies have confirmed that metformin inhibits …

Mitochondrial metabolic determinants of multiple myeloma growth, survival, and therapy efficacy

R Nair, P Gupta, M Shanmugam - Frontiers in Oncology, 2022 - frontiersin.org
Multiple myeloma (MM) is a plasma cell dyscrasia characterized by the clonal proliferation of
antibody producing plasma cells. Despite the use of next generation proteasome inhibitors …

[HTML][HTML] Single-cell RNA sequencing reveals XBP1-SLC38A2 axis as a metabolic regulator in cytotoxic T lymphocytes in multiple myeloma

Y Wan, M Chen, X Li, X Han, L Zhong, F Xiao, J Liu… - Cancer Letters, 2023 - Elsevier
The mechanisms underlying the functional impairment and metabolic reprogramming of T
lymphocytes in multiple myeloma (MM) have not been fully elucidated. In this study, single …

Lipid metabolic vulnerabilities of multiple myeloma

R Torcasio, ME Gallo Cantafio, RK Ikeda… - Clinical and …, 2023 - Springer
Multiple myeloma (MM) is the second most common hematological malignancy worldwide,
characterized by abnormal proliferation of malignant plasma cells within a tumor-permissive …

11C-Methionine PET/CT in Assessment of Multiple Myeloma Patients: Comparison to 18F-FDG PET/CT and Prognostic Value

MI Morales-Lozano, P Rodriguez-Otero… - International Journal of …, 2022 - mdpi.com
Multiple myeloma (MM) is the second most common haematological malignancy and
remains incurable despite therapeutic advances. 18F-FDG (FDG) PET/CT is a relevant tool …

A leukemic target with a thousand faces: The mitochondria

B Maffeo, C Panuzzo, A Moraca, D Cilloni - International Journal of …, 2023 - mdpi.com
In the era of personalized medicine greatly improved by molecular diagnosis and tailor-
made therapies, the survival rate of acute myeloid leukemia (AML) at 5 years remains …

Head-to-head comparison of [68Ga]Ga-PSMA-11 and [18F]FDG PET/CT in multiple myeloma

SPM Souza, FC Frasson, MES Takahashi… - European journal of …, 2023 - Springer
Purpose The aim of this study was to compare [18F] FDG and [68Ga] Ga-PSMA-11 PET/CT
image findings in patients with multiple myeloma (MM). Methods Twenty consecutive …

Ferroptosis in hematological malignant tumors

Y Liu, Z Du, J Huang, T Li, J Zhang, Y Li, W Yi… - Frontiers in …, 2023 - frontiersin.org
Ferroptosis is a kind of iron-dependent programmed cell death discovered in recent years.
Its main feature is the accumulation of lipid reactive oxygen species in cells, eventually …