Because of their potent antitumor activity and their proinflammatory role, natural killer (NK)
cells are at the forefront of efforts to develop immuno-oncologic treatments. NK cells …

Natural killer (NK) cells are innate immune cells that are critical to the body's antitumor and
antimetastatic defense. As such, novel therapies are being developed to utilize NK cells as …

White blood cells (WBCs) are a major component of immunity in response to pathogen
invasion. Neutrophils are the most abundant WBCs in humans, playing a central role in …

Studies were performed to characterize the effector cells responsible for natural cytotoxicity
of mouse lymphoid cells against a variety of syngeneic and allogeneic tumor lines. Since …

Multiple effector layers in the immune system ensure an optimal temporal and spatial
distribution of immune defense. Cytotoxic innate lymphoid natural killers (NK) and adaptive …

Natural killer (NK) cells play a pivotal role in cancer immunotherapy due to their innate
ability to detect and kill tumorigenic cells. The decision to kill is determined by the …

Immunological memory is a hallmark of the adaptive immune system. However, the ability to
remember and respond more robustly against a second encounter with the same pathogen …

A transplantable, murine reticulum cell sarcoma is described which exhibits the cytologic,
adherence, and phagocytic properties of macrophages. It forms specific rosettes with …

Publisher Summary The term “cell-mediated cytotoxicity” applies to lytic reactions that
require the participation of lymphoid or non-lymphoid cells but not of added complement. It …

Increased evidence of cross-talk between NK cells and other immune cells has enhanced
the possibilities of exploiting the interplay between the activation and inhibition of NK cells …