Lipid interaction with α-synuclein (αSyn) has been long implicated in the pathogenesis of
Parkinson's disease (PD). However, it has not been fully determined which lipids are …

Background LRRK2 mutations are a common cause of dominantly inherited PD. Previous
studies showed decreases in urine levels of didocohexaenoyl (22: 6) bis (monoacylglycerol) …

Advances over the past decade have improved our understanding of the role of sphingolipid
in the onset and progression of Parkinson's disease. Much attention has been paid to …

Parkinson's disease (PD) is a complex and progressive neurodegenerative disorder with a
prevalence of approximately 0.5–1% among those aged 65–70 years. Although most of its …

We quantified concentrations of three isoforms of the endolysosomal lipid, bis
(monoacylglycerol) phosphate (BMP) in the urine of deeply phenotyped cohorts in the …

Parkinson's disease (PD) and atypical parkinsonian syndromes (APS) are symptomatically
characterized by parkinsonism, with the latter presenting additionally a distinctive range of …

Parkinson's disease (PD) is the second most common neurodegenerative disorder after
Alzheimer's disease, and its prevalence is increasing with age. A wealth of genetic evidence …

Age-associated neurodegenerative diseases such as amyotrophic lateral sclerosis (ALS),
Parkinson's disease (PD) and Alzheimer's disease (AD) are an unmet health need, with …

Lysosomes are specialized organelles with an acidic pH that act as recycling hubs for
intracellular and extracellular components. They harbour numerous different hydrolytic …

GBA variants increase the risk of Parkinson's disease (PD) by 10 times. The GBA gene
encodes the lysosomal enzyme glucocerebrosidase (GCase). The p. N370S substitution …