Parkinson's disease (PD) is a neurodegenerative disorder pathologically distinguished by
degeneration of dopaminergic neurons in the substantia nigra pars compacta. Muscle …

Studies investigating the associations between genetic or environmental factors and
Parkinson's disease (PD) have uncovered a number of factors shared with cardiovascular …

In recent years, multiple lines of evidence from human genetic and molecular studies have
highlighted the importance of the autophagy lysosomal pathway (ALP) in Parkinson's …

The accumulation and misfolding of αsynuclein (αsyn) represent the main pathological
hallmark of PD. Overexpression of αsyn and failure of cellular protein degradation systems …

Maintenance of mitochondrial health is essential for neuronal survival and relies upon
dynamic changes in the mitochondrial network and effective mitochondrial quality control …

Recently, the genetic variability in lysosomal storage disorders has been implicated in the
pathogenesis of Parkinson's disease. Here, we found that variants in prosaposin (PSAP), a …

Abstract Central Nervous System (CNS) diseases, such as Alzheimer's diseases (AD),
Parkinson's Diseases (PD), brain tumors, Huntington's disease (HD), and stroke, still remain …

Parkinson's disease (PD) is a degenerative movement disorder resulting from the loss of
specific neuron types in the midbrain. Early environmental and pathophysiological studies …

Since the initial identification of alpha-synuclein (α-syn) at the synapse, numerous studies
demonstrated that α-syn is a key player in the etiology of Parkinson's disease (PD) and other …

Early-onset parkinsonism (EO parkinsonism), defined as subjects with disease onset before
the age of 40 or 50 years, can be the main clinical presentation of a variety of conditions that …