Osteoarthritis (OA) is the most common degenerative joint disease that causes painful
swelling and permanent damage to the joints in the body. The molecular mechanisms of OA …

Orofacial pain refers to pain occurring in the head and face, which is highly prevalent and
represents a challenge to clinicians, but its underlying mechanisms are not fully understood …

Temporomandibular joint osteoarthritis (TMJOA) condylar cartilage degeneration and
abnormal subchondral bone pathological remodeling induce pain and joint dysfunction, and …

One of the most controversial aspects of the use of animals in science is the production of
pain. Pain is a central ethical concern. The activation of neural pathways involved in the pain …

Temporomandibular joint disorders (TMDs) are conditions that affect the muscles of
mastication and joints that connect the mandible to the base of the skull. Although TMJ …

Chronic pain in temporomandibular disorder (TMD) is a common health problem.
Cumulating evidence indicates that the etiology of TMD pain is complex with multifactorial …

Abstract Bground Information Ferroptosis contributes to temporomandibular joint
osteoarthritis (TMJOA) lesion development and is still poorly understood. Results In this …

Background An evident association between mood disorders and TMJ dysfunction has been
demonstrated in previous studies. This study observed both the behavioral changes and the …

Background/purpose The temporomandibular joint (TMJ) is a bi-arthrodial joint that is
composed of the temporal bone glenoid fossa and the condylar head of the mandible both …

Temporomandibular joint osteoarthritis (TMJ OA) occurs in 8 to 16% of the population.
Currently available animal models do not faithfully simulate the native disease progression …