Aging of the brain can manifest itself as a memory and cognitive decline, which has been
shown to frequently coincide with changes in the structural plasticity of dendritic spines …

Lactate in the brain has long been associated with ischaemia; however, more recent
evidence shows that it can be found there under physiological conditions. In the brain …

Aging is among the most important risk factors for morbidity and mortality. To contribute
toward a molecular understanding of aging, we analyzed age-resolved transcriptomic data …

Growing evidence suggests that synaptic signaling is compromised in the aging brain and in
Alzheimer's disease (AD), contributing to synaptic decline. Wnt signaling is a prominent …

Microglia are the predominant immune response cells and professional phagocytes of the
central nervous system (CNS) that have been shown to be important for brain development …

Postoperative cognitive dysfunction (POCD) is defined by cognitive impairment determined
by neuropsychological tests from before to after surgery. Several mechanisms have been …

In mammals, recent studies have demonstrated that the brain, the hypothalamus in
particular, is a key bidirectional integrator of humoral and neural information from peripheral …

Synapses are functionally distinct neuronal compartments that are critical for brain function,
with synaptic dysfunction being an early pathological feature in aging and disease. Given …

With an increasingly ageing population that is expected to double by 2050 in the US, it is
paramount that we further understand the neurological changes that occur during ageing …

The adult central nervous system (CNS) contains resident stem cells within specific niches
that maintain a self-renewal and proliferative capacity to generate new neurons, astrocytes …