Human–gut bacterial protein–protein interactions: understudied but impactful to human health

D Balint, IL Brito - Trends in Microbiology, 2023 - cell.com
The human gut microbiome is associated with a wide range of diseases; yet, the
mechanisms these microbes use to influence human health are not fully understood. Protein …

[HTML][HTML] Pathobionts in inflammatory bowel disease: origins, underlying mechanisms, and implications for clinical care

A Gilliland, JJ Chan, TJ De Wolfe, H Yang, BA Vallance - Gastroenterology, 2023 - Elsevier
The gut microbiota plays a significant role in the pathogenesis of both forms of inflammatory
bowel disease (IBD), namely Crohn's disease (CD) and ulcerative colitis (UC). While …

Manipulating the gut and tumor microbiota for immune checkpoint inhibitor therapy: from dream to reality

N Guillot, B Roméo, SS Manesh, G Milano… - Trends in Molecular …, 2023 - cell.com
The past decade has witnessed a revolution in cancer treatment by shifting from
conventional therapies to immune checkpoint inhibitors (ICIs). These immunotherapies …

High-throughput transcriptomics of 409 bacteria–drug pairs reveals drivers of gut microbiota perturbation

D Ricaurte, Y Huang, RU Sheth, DR Gelsinger… - Nature …, 2024 - nature.com
Many drugs can perturb the gut microbiome, potentially leading to negative health
consequences. However, mechanisms of most microorganism–drug responses have not …

Targeted delivery of the probiotic Saccharomyces boulardii to the extracellular matrix enhances gut residence time and recovery in murine colitis

MK Heavey, A Hazelton, Y Wang, M Garner… - Nature …, 2024 - nature.com
Probiotic and engineered microbe-based therapeutics are an emerging class of
pharmaceutical agents. They represent a promising strategy for treating various chronic and …

[HTML][HTML] Inflammatory bowel disease–associated intestinal fibrosis

JM Park, J Kim, YJ Lee, SU Bae… - Journal of pathology and …, 2023 - ncbi.nlm.nih.gov
Fibrosis is characterized by a proliferation of fibroblasts and excessive extracellular matrix
following chronic inflammation, and this replacement of organ tissue with fibrotic tissue …

An Inflammatory Bowel Diseases Integrated Resources Portal (IBDIRP)

N Kai, C Qingsong, M Kejia, L Weiwei, W Xing… - Database, 2024 - academic.oup.com
IBD, including ulcerative colitis and Crohn's disease, is a chronic and debilitating
gastrointestinal disorder that affects millions of people worldwide. Research on IBD has …

[HTML][HTML] Protein Language Models Uncover Carbohydrate-Active Enzyme Function in Metagenomics

K Thurimella, AMT Mohamed, DB Graham, RM Owens… - bioRxiv, 2023 - ncbi.nlm.nih.gov
In metagenomics, the pool of uncharacterized microbial enzymes presents a challenge for
functional annotation. Among these, carbohydrate-active enzymes (CAZymes) stand out due …

Disease signatures in the gut metagenome of a prospective family cohort of inflammatory bowel disease

MC Ruehlemann, S Waschina, EM Wacker, P Rausch… - medRxiv, 2023 - medrxiv.org
Inflammatory bowel disease (IBD) is associated with dysbiotic microbiomes. However,
whether microbiomes of family members of IBD patients harbour microbial disease …

猪源罗伊氏乳杆菌LR1 对断奶仔猪肠黏膜细胞外基质动态变化的影响.

易宏波, 刘春艳, 韦洋洋, 杨雪芬… - Guangdong …, 2023 - search.ebscohost.com
[目的] 初步研究饲粮添加猪源罗伊氏乳杆菌对断奶仔猪肠道细胞外基质(Extracellular matrix,
ECM) 表达的影响, 为猪源罗伊氏乳杆菌在畜牧业中的推广应用提供参考.[方法] 选取21 …