Human–gut bacterial protein–protein interactions: understudied but impactful to human health
The human gut microbiome is associated with a wide range of diseases; yet, the
mechanisms these microbes use to influence human health are not fully understood. Protein …
mechanisms these microbes use to influence human health are not fully understood. Protein …
[HTML][HTML] Pathobionts in inflammatory bowel disease: origins, underlying mechanisms, and implications for clinical care
The gut microbiota plays a significant role in the pathogenesis of both forms of inflammatory
bowel disease (IBD), namely Crohn's disease (CD) and ulcerative colitis (UC). While …
bowel disease (IBD), namely Crohn's disease (CD) and ulcerative colitis (UC). While …
Manipulating the gut and tumor microbiota for immune checkpoint inhibitor therapy: from dream to reality
N Guillot, B Roméo, SS Manesh, G Milano… - Trends in Molecular …, 2023 - cell.com
The past decade has witnessed a revolution in cancer treatment by shifting from
conventional therapies to immune checkpoint inhibitors (ICIs). These immunotherapies …
conventional therapies to immune checkpoint inhibitors (ICIs). These immunotherapies …
High-throughput transcriptomics of 409 bacteria–drug pairs reveals drivers of gut microbiota perturbation
Many drugs can perturb the gut microbiome, potentially leading to negative health
consequences. However, mechanisms of most microorganism–drug responses have not …
consequences. However, mechanisms of most microorganism–drug responses have not …
Targeted delivery of the probiotic Saccharomyces boulardii to the extracellular matrix enhances gut residence time and recovery in murine colitis
MK Heavey, A Hazelton, Y Wang, M Garner… - Nature …, 2024 - nature.com
Probiotic and engineered microbe-based therapeutics are an emerging class of
pharmaceutical agents. They represent a promising strategy for treating various chronic and …
pharmaceutical agents. They represent a promising strategy for treating various chronic and …
[HTML][HTML] Inflammatory bowel disease–associated intestinal fibrosis
JM Park, J Kim, YJ Lee, SU Bae… - Journal of pathology and …, 2023 - ncbi.nlm.nih.gov
Fibrosis is characterized by a proliferation of fibroblasts and excessive extracellular matrix
following chronic inflammation, and this replacement of organ tissue with fibrotic tissue …
following chronic inflammation, and this replacement of organ tissue with fibrotic tissue …
An Inflammatory Bowel Diseases Integrated Resources Portal (IBDIRP)
N Kai, C Qingsong, M Kejia, L Weiwei, W Xing… - Database, 2024 - academic.oup.com
IBD, including ulcerative colitis and Crohn's disease, is a chronic and debilitating
gastrointestinal disorder that affects millions of people worldwide. Research on IBD has …
gastrointestinal disorder that affects millions of people worldwide. Research on IBD has …
[HTML][HTML] Protein Language Models Uncover Carbohydrate-Active Enzyme Function in Metagenomics
In metagenomics, the pool of uncharacterized microbial enzymes presents a challenge for
functional annotation. Among these, carbohydrate-active enzymes (CAZymes) stand out due …
functional annotation. Among these, carbohydrate-active enzymes (CAZymes) stand out due …
Disease signatures in the gut metagenome of a prospective family cohort of inflammatory bowel disease
Inflammatory bowel disease (IBD) is associated with dysbiotic microbiomes. However,
whether microbiomes of family members of IBD patients harbour microbial disease …
whether microbiomes of family members of IBD patients harbour microbial disease …
猪源罗伊氏乳杆菌LR1 对断奶仔猪肠黏膜细胞外基质动态变化的影响.
易宏波, 刘春艳, 韦洋洋, 杨雪芬… - Guangdong …, 2023 - search.ebscohost.com
[目的] 初步研究饲粮添加猪源罗伊氏乳杆菌对断奶仔猪肠道细胞外基质(Extracellular matrix,
ECM) 表达的影响, 为猪源罗伊氏乳杆菌在畜牧业中的推广应用提供参考.[方法] 选取21 …
ECM) 表达的影响, 为猪源罗伊氏乳杆菌在畜牧业中的推广应用提供参考.[方法] 选取21 …