Heart disease is the main cause of death worldwide. Because death of the myocardium is
irreversible, it remains a significant clinical challenge to rescue myocardial deficiency …

The introduction of more relevant cell models in early preclinical drug discovery, combined
with high-content imaging and automated analysis, is expected to increase the quality of …

Previous studies have developed vascularized tumor spheroid models to demonstrate the
impact of intravascular flow on tumor progression and treatment. However, these models …

Tumor progression relies on the interaction between neoplastic epithelial cells and their
surrounding stromal partners. This cell cross‐talk affects stromal development, and …

Conventional tissue engineering, cell therapy, and current medical approaches were shown
to be successful in reducing mortality rate and complications caused by cardiovascular …

The tumor microenvironment contributes significantly to tumor initiation, progression, and
resistance to chemotherapy. Much of our understanding of the tumor and its …

While being the rarest skin cancer, melanoma is also the deadliest. To further drug discovery
and improve clinical translation, new human cell-based in vitro models are needed. Our …

Vascularization of reconstructed tissues is one of the remaining hurdles to be considered to
improve both the functionality and viability of skin grafts and the relevance of in vitro …

Cancer 'genetic dependencies'—genes whose products are essential for cancer cell fitness—
are promising targets for therapeutic development. However, recent evidence has cast doubt …

Multiple sharp‐edged gold nanostars were efficiently assembled on nanopipette tips
through electrostatic interactions for use as a potent intracellular hypoxia‐sensing Raman …