Vascularization of reconstructed tissues is one of the remaining hurdles to be considered to
improve both the functionality and viability of skin grafts and the relevance of in vitro …

Simple Summary The tumour microenvironment is composed of multiple non-cancerous
cells that communicate with the tumour cells, influencing their behaviour and impacting the …

Micropatterned suspension culture creates consistently sized and shaped cell aggregates
but has not produced organotypic structures from stable cells, thus restricting its use in …

Lung malignancies accounted for 11% of cancers worldwide in 2020 and remained the
leading cause of cancer deaths. About 80% of lung cancers belong to non-small cell lung …

Endothelial cells (ECs) are an important component of the tumor microenvironment, playing
key roles in tumor development and progression that span from angiogenesis to immune …

Imaging live cells in a three-dimensional (3D) culture system yields more accurate
information and spatial visualization of the interplay of cells and the surrounding matrix …

Glioblastoma is one of the most aggressive tumours with a poor response to treatment and a
poor prognosis for patients. One of the proteins expressed in glioblastoma tissue is CHI3L1 …

An intensive investigation of the development of in vitro models to study tumor biology has
led to the generation of various three-dimensional (3D) culture methods that better mimic in …

It is recognized that tumors do not exist and grow as isolated entities of neoplastic cells, but
rather in continuous and bidirectional communication with adjacent stromal cells. Stromal …

Although the current medical treatments have been successful in reducing the coronary
heart disease related mortality rate, however there still exist various challenges in cardiac …