Three-dimensional spheroids of cancer cells are important tools for both cancer drug
screens and for gaining mechanistic insight into cancer cell biology. The power of this …

Vascularization of engineered tissue constructs remains one of the greatest unmet
challenges to mimicking the native tissue microenvironment in vitro. The main obstacle is …

Phospholipases A2 (PLA2) represent a superfamily of enzymes widely distributed in living
organisms, with a broad spectrum of pharmacological activities and therapeutic potential …

Solid tumors in advanced cancer often feature a structurally and functionally abnormal
vasculature through tumor angiogenesis, which contributes to cancer progression …

Cancer is the leading cause of death worldwide. Unfortunately, efforts to understand this
disease are confounded by the complex, heterogenous tumor microenvironment (TME) …

Simple Summary Photodynamic therapy (PDT) eradicates tumors by the local activation of a
photosensitizer with appropriate light. Although very promising, its clinical application is …

Blood and lymphatic vessels are regulators of physiological processes, including
oxygenation and fluid transport. Both vessels are ubiquitous throughout the body and are …

Despite the enormous progress and development of modern therapies, lung cancer remains
one of the most common causes of death among men and women. The key element in the …

Lung cancer is the most frequently diagnosed cancer worldwide and the one that causes the
highest mortality. In order to understand the disease and to develop new treatments, in vitro …

Lymphangiogenesis, or formation of new lymphatic vessels, is a tightly regulated process
that is controlled by growth factor signaling and biomechanical cues. Lymphatic endothelial …