Objective Cancer is a heterogenic disease from genetic to individual levels, which induced a
variety of therapheutical research and disease progression. Cancer heterogeneity were also …

Hypoxia is the most common microenvironment feature of lung cancer tumors, which affects
cancer progression, metastasis and metabolism. Oxygen induces both proteomic and …

The tumour microenvironment plays a critical role in tumour progression and drug resistance
processes. Non-malignant cell players, such as fibroblasts, endothelial cells, immune cells …

Scaffold-free tissue engineering is desired in creating consistently sized and shaped cell
aggregates but has been limited to spheroid-like structure and function, thus restricting its …

Résumé L'objectif de ce travail a consisté à évaluer le rôle d'un microenvironnement avec
une haplo-insuffisance hétérozygote du gène BRCA1 dans les événements précoces de la …

BACKGROUND: Endothelial cells (ECs) line the blood vessel lumen and respond to fluid
shear stress. ECs are also responsible for initiating the formation of new blood vessels …

Glioblastoma is the most common primary tumor in the central nervous system. With an
incidence of 3–5 out of 100,000 persons in Western countries, glioblastoma is one of the …

Cell therapies (CT), together with the high throughput (HT) production of pre-vascularized
spheroids, are likely to play a pivotal role in the next generation of healthcare, owing to their …

Photochemical internalisation (PCI) is a method for enhancing delivery of drugs such as
cytotoxins to their intracellular target sites of action through the use of low dose …