Cancer encompasses a complex, heterogeneous and dynamic group of diseases that arise
from perturbations to multiple biological networks within the body. A systems biology-based …

As a DNA receptor in the cytoplasm, cyclic GMP-AMP synthase (cGAS) contributes to the
recognition of abnormal DNA in the cytoplasm and contributes to the stimulator of interferon …

Background Despite the critical roles of Th1-polarised CD4+ T cells in cancer
immunosurveillance, the translation of their potential to clinical use remains challenging …

Application of contemporary molecular biology techniques to clinical samples in oncology
resulted in the accumulation of unprecedented experimental data. These “omics” data are …

Immunotherapy has become a standard treatment in many cancers and it is based on three
main therapeutic axes: immune checkpoint blockade (ICB), vaccination and adoptive cell …

Purpose: The low mutational load of some cancers is considered one reason for the difficulty
to develop effective tumor vaccines. To overcome this problem, we developed a strategy to …

Immunotherapy has revolutionized the standard of care for a range of malignancies.
Accumulating evidence suggests that the success of immunotherapy is likely attributable to …

Neoantigens are tumor-specific proteins and peptides that can be highly immunogenic.
Immune-mediated tumor rejection is strongly associated with cytotoxic responses to …

To explore the signature function of the tumor mutational burden (TMB) and potential
biomarkers in prostate cancer (PCa), transcriptome profiles, somatic mutation data, and …

Purpose: Recent studies have demonstrated HLA class II (HLA-II)–dependent killing of
melanoma cells by cytotoxic CD4 T cells. We investigated evolution of HLA-II–loss tumors …