Abstract PI3K (phosphoinositide 3-kinase)/AKT and RAS/MAPK (mitogen-activated protein
kinase) pathway coactivation in the prostate epithelium promotes both epithelial …

Taxanes–docetaxel and cabazitaxel–are the most active chemotherapy drugs currently used
for the treatment of metastatic castration-resistant prostate cancer (mCRPC). However …

Cellular plasticity lies at the core of cancer progression, metastasis, and resistance to
treatment. Stemness and epithelial-mesenchymal plasticity in cancer are concepts that …

A high number of cancer-related deaths (up to 90) are due to metastasis and simple
definition of metastasis is new colony formation of tumor cells in a secondary site. In tumor …

Prostate cancer (PCa) is a common cancer in men that is curable prior to metastasis, when
its prognosis worsens. Chondroitin sulfate (CS) is found in the extracellular matrix of normal …

Background The chemoresistance of prostate cancer (PCa) is invariably associated with the
aggressiveness and metastasis of this disease. New emerging evidence indicates that the …

The increasing incidence of resistance to chemotherapeutic agents has become a major
issue in the treatment of oral cancer (OC). Epithelial-mesenchymal transition (EMT) has …

Tumor heterogeneity is common in cancer, however recent studies have applied single
gene expression signatures to classify bladder cancers into distinct subtypes. Such …

Advanced prostate adenocarcinomas enriched in stem-cell features, as well as variant
androgen receptor (AR)-negative neuroendocrine (NE)/small-cell prostate cancers are …

Epithelial-mesenchymal transition (EMT) is a complicated molecular process that governs
cellular shape and function changes throughout tissue development and embryogenesis. In …